B cells in chronic obstructive pulmonary disease: moving to center stage
| Autor: | Leen J M Seys, Ken R. Bracke, Caroline A. Owen, Francesca Polverino |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Chronic bronchitis Physiology T cell Autoimmunity Inflammation Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Immune system Physiology (medical) Animals Humans Immunologic Factors Medicine B cell B-Lymphocytes Immunity Cellular COPD Innate immune system business.industry Autoantibody Cell Biology medicine.disease respiratory tract diseases 030104 developmental biology medicine.anatomical_structure 030228 respiratory system Immunology Call for Papers Disease Progression Cytokines medicine.symptom business |
| Zdroj: | American Journal of Physiology-Lung Cellular and Molecular Physiology. 311:L687-L695 |
| ISSN: | 1522-1504 1040-0605 |
| DOI: | 10.1152/ajplung.00304.2016 |
| Popis: | Chronic inflammatory responses in the lungs contribute to the development and progression of chronic obstructive pulmonary disease (COPD). Although research studies focused initially on the contributions of the innate immune system to the pathogenesis of COPD, more recent studies have implicated adaptive immune responses in COPD. In particular, studies have demonstrated increases in B cell counts and increases in the number and size of B cell-rich lymphoid follicles in COPD lungs that correlate directly with COPD severity. There are also increases in lung levels of mediators that promote B cell maturation, activation, and survival in COPD patients. B cell products such as autoantibodies directed against lung cells, components of cells, and extracellular matrix proteins are also present in COPD lungs. These autoantibodies may contribute to lung inflammation and injury in COPD patients, in part, by forming immune complexes that activate complement components. Studies of B cell-deficient mice and human COPD patients have linked B cells most strongly to the emphysema phenotype. However, B cells have protective activities during acute exacerbations of COPD by promoting adaptive immune responses that contribute to host defense against pathogens. This review outlines the evidence that links B cells and B cell-rich lymphoid follicles to the pathogenesis of COPD and the mechanisms involved. It also reviews the potential and limitations of B cells as therapeutic targets to slow the progression of human COPD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|