Analysis of reflux as the aetiology of laryngeal dysplasia progression through a matched case‐control study
| Autor: | Yanyan Niu, Zhi-Yong Liang, Xiaofeng Jin, Wei Gu, Hong Huo, Jian Wang, Wen-Ze Wang |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Larynx medicine.medical_specialty Bilirubin Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pepsin Internal medicine medicine Humans Risk factor 030223 otorhinolaryngology Prospective cohort study Laryngeal Neoplasms Aged Aged 80 and over Univariate analysis Hyperplasia biology business.industry Reflux Case-control study Middle Aged Pepsin A Enteropeptidase medicine.anatomical_structure Otorhinolaryngology chemistry Case-Control Studies 030220 oncology & carcinogenesis Gastroesophageal Reflux biology.protein Female business |
| Zdroj: | Clinical Otolaryngology. 46:175-180 |
| ISSN: | 1749-4486 1749-4478 |
| DOI: | 10.1111/coa.13638 |
| Popis: | OBJECTIVES Laryngeal dysplasia (LD) is a precancerous lesion of the larynx. In this study, the laryngeal tissue of patients with laryngeal dysplasia was taken as the research object, and the aetiology of reflux was analysed. METHOD Patients with laryngeal dysplasia after surgery were selected as our subjects. The levels of pepsin, enterokinase and bilirubin in laryngeal tissue samples of the two groups were detected by immunohistochemical method. RESULTS The OR values (95% CI) of pepsin, enterokinase and bilirubin were 0.67 (0.19-2.36), 0.80 (0.22-2.98) and 1.33 (0.30-5.96), respectively, in the univariate analysis. Besides, in the multivariate analysis, the OR values (95% CI) of pepsin, enterokinase and bilirubin were 0.57 (0.14-2.30), 0.73 (0.18-2.92) and 1.40 (0.30-6.53), respectively. CONCLUSION Larger sample size should be applied to prospective studies on whether reflux is a risk factor for laryngeal cancer. |
| Databáze: | OpenAIRE |
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