Cocaine alters glutamic acid decarboxylase differentially in the nucleus accumbens core and shell
Autor: | Peter W. Kalivas, Barbara A. Sorg, M. Stacy Hooks, Barbara J.M. Guminski |
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Rok vydání: | 1995 |
Předmět: |
Male
medicine.medical_specialty Preprotachykinin Glutamate decarboxylase Striatum Nucleus accumbens Biology gamma-Aminobutyric acid Drug Administration Schedule Nucleus Accumbens Rats Sprague-Dawley Cellular and Molecular Neuroscience Cocaine Dopamine receptor D2 Internal medicine Tachykinins Basal ganglia medicine Animals RNA Messenger Protein Precursors Molecular Biology gamma-Aminobutyric Acid Neurons Analysis of Variance Glutamate Decarboxylase Receptors Dopamine D2 Glutamic acid Enkephalins Rats Endocrinology Genetic Code medicine.drug |
Zdroj: | Brain research. Molecular brain research. 29(2) |
ISSN: | 0169-328X |
Popis: | The effects of acute and repeated daily cocaine on the levels of mRNA coding for glutamic acid decarboxylase (GAD), preproenkephalin (PPE), preprotachykinin (PPT), and the dopamine D2 receptor were determined in the striatum, nucleus accumbens core and shell areas (NAcore, NAshell), and medial prefrontal cortex. Rats were given repeated saline or cocaine for 6 days. A cocaine challenge administered 24 h later resulted in an augmented locomotor response in daily cocaine-pretreated rats. Six h after the challenge, rats were sacrificed and Northern blot analysis revealed that acute cocaine increased GAD mRNA levels by 44% in the NAshell, while repeated cocaine prevented the acute cocaine-induced increase. These data suggest that cocaine may differentially regulate GABA release at NA core and shell projection fields. |
Databáze: | OpenAIRE |
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