Green synthesized cerium oxide nanoparticle: A prospective drug against oxidative harm
| Autor: | Tarakdas Basu, Milon Banik, Riya Mukherjee, Mousumi Patra, Debanjan Dutta, Rakhi Dasgupta, Manabendra Mukherjee |
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| Rok vydání: | 2016 |
| Předmět: |
Cerium oxide
Antioxidant Cell Survival medicine.medical_treatment Inorganic chemistry Nanoparticle chemistry.chemical_element 02 engineering and technology Crystal structure Oxidative phosphorylation 010402 general chemistry 01 natural sciences Oxygen Antioxidants chemistry.chemical_compound Mice Neuroblastoma Colloid and Surface Chemistry medicine Tumor Cells Cultured Animals Prospective Studies Physical and Theoretical Chemistry Aloe Plant Extracts Surfaces and Interfaces General Medicine Cerium Hydrogen Peroxide Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Oxidants 0104 chemical sciences Cerium nitrate Plant Leaves chemistry Nanoparticles 0210 nano-technology Reactive Oxygen Species Oxidation-Reduction Biotechnology |
| Zdroj: | Colloids and surfaces. B, Biointerfaces. 147 |
| ISSN: | 1873-4367 |
| Popis: | Cerium oxide nanoparticle (CeONP) of size 2-3nm was synthesized by a new, simple and green method at ambient temperature, using cerium nitrate as prime precursor and Aloe vera leaf extract as stabilizing agent. Of the two oxidation states (+3) and (+4) of cerium, it was dominantly present in (+3) state in CeONP and cyclic conversion of Ce(III)O→Ce(IV)O→Ce(III)O by reaction with H2O2 implied uninterrupted antioxidant property of CeONP. Moreover, the higher oxygen defect in the crystal lattice produced particles with higher antioxidant activity. CeONP was found to neutralize the deleterious effects of H2O2 viz., cell death, generation of intracellular reactive oxygen species and loss of connectivity in mouse neural cells. Therefore, CeONP might have potential use in future as an anti-oxidant drug. |
| Databáze: | OpenAIRE |
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