Contrast Enhanced Superharmonic Imaging for Acoustic Angiography Using Reduced Form-Factor Lateral Mode Transmitters for Intravascular and Intracavity Applications
| Autor: | Paul A. Dayton, K. Heath Martin, Xiaoning Jiang, Wenbin Huang, Zhuochen Wang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Acoustics and Ultrasonics
Acoustics Transducers Second-harmonic imaging microscopy Contrast Media 01 natural sciences Signal Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine 0103 physical sciences Intravascular ultrasound medicine Humans Electrical and Electronic Engineering 010301 acoustics Instrumentation Ultrasonography Physics Microbubbles medicine.diagnostic_test business.industry Ultrasound Angiography Equipment Design Transducer Ultrasonic sensor business |
| Zdroj: | IEEE transactions on ultrasonics, ferroelectrics, and frequency control. 64(2) |
| ISSN: | 1525-8955 |
| Popis: | Techniques to image the microvasculature may play an important role in imaging tumor-related angiogenesis and vasa vasorum associated with vulnerable atherosclerotic plaques. However, the microvasculature associated with these pathologies is difficult to detect using traditional B-mode ultrasound or even harmonic imaging due to small vessel size and poor differentiation from surrounding tissue. Acoustic angiography, a microvascular imaging technique that utilizes superharmonic imaging (detection of higher order harmonics of microbubble response), can yield a much higher contrast-to-tissue ratio than second harmonic imaging methods. In this paper, two dual-frequency transducers using lateral mode transmitters were developed for superharmonic detection and acoustic angiography imaging in intracavity applications. A single element dual-frequency intravascular ultrasound transducer was developed for concept validation, which achieved larger signal amplitude, better contrast-to-noise ratio (CNR), and pulselength compared to the previous work. A dual-frequency [Pb(Mg1/3Nb2/3)O3]-x[PbTiO3] array transducer was then developed for superharmonic imaging with dynamic focusing. The axial and lateral sizes of the microbubbles in a 200- [Formula: see text] tube were measured to be 269 and [Formula: see text], respectively. The maximum CNR was calculated to be 22 dB. These results show that superharmonic imaging with a low frequency lateral mode transmitter is a feasible alternative to thickness mode transmitters when the final transducer size requirements dictate design choices. |
| Databáze: | OpenAIRE |
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