Organic Radical Contrast Agents for Magnetic Resonance Imaging
| Autor: | Sandra S. Eaton, Deborah G. Mitchell, Gareth R. Eaton, Andrzej Rajca, Michael A. Swanson, Ying Wang, Arnon Olankitwanit, Suchada Rajca, Michael D. Boska, Joseph T. Paletta |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Nitroxide mediated radical polymerization
medicine.diagnostic_test Extramural Organic chemicals Radical Magnetic resonance imaging General Chemistry Conjugated system Photochemistry Biochemistry Catalysis Article chemistry.chemical_compound Colloid and Surface Chemistry Nuclear magnetic resonance chemistry Dendrimer medicine Ethylene glycol |
| Popis: | We report a molecular design that provides an intravenously injectable organic radical contrast agent (ORCA) for which the molecular 1H water relaxivity (r1) is ca. 5 mM–1 s–1. The ORCA is based on spirocyclohexyl nitroxide radicals and poly(ethylene glycol) chains conjugated to a fourth-generation polypropylenimine dendrimer scaffold. The metal-free ORCA has a long shelf life and provides selectively enhanced magnetic resonance imaging in mice for over 1 h. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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