Effect of serotonin on the motility of smooth muscles in teats of lactating cows
| Autor: | Georgette Vandeputte-Van Messom, Christian Burvenich, Georges Peeters |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.medical_specialty
Serotonin Ketanserin Methysergide Motility Mianserin Mammary Glands Animal Piperidines Pregnancy Internal medicine medicine Animals Lactation Udder Milk Ejection Chemistry food and beverages Muscle Smooth General Medicine medicine.anatomical_structure Endocrinology Muscle Tonus Sphincter Tonicity Animal Science and Zoology Cattle Female Serotonin Antagonists Food Science medicine.drug Muscle Contraction |
| Zdroj: | The Journal of dairy research. 52(3) |
| ISSN: | 0022-0299 |
| Popis: | SUMMARYThe effects of serotonin, injected into one udder artery, on teat smooth muscle function were investigated in four lactating cows. Motility of longitudinal smooth muscles was recorded by a plethysmographic technique, and sphincter function by measuring milk leakage from the full udder. Serotonin (40, 120 and 360 μg) activated teat muscle tonicity and reduced the volume of milk leakage. The effects on longitudinal smooth muscles were reduced by mianserin and ketanserin (0·375, 1·5 and 6 mg) and by methysergide (1·5 mg). These blocking substances were also effective (0·2, 0·6 and 1·8 mg respectively) in antagonizing the inhibiting action of serotonin on milk leakage. It is suggested that serotonin effects are mediated by receptors of the S2-type. |
| Databáze: | OpenAIRE |
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