Vanadium Decreases Hepcidin mRNA Gene Expression in STZ-Induced Diabetic Rats, Improving the Anemic State
| Autor: | Cristina Sánchez-González, Pilar Aranda, Julio Gálvez, Francesca Algieri, Lorenzo Rivas-García, Juan Llopis, Maria Montes-Bayón, Alba Rodríguez-Nogales |
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| Přispěvatelé: | [Sánchez-González,C, Rivas-García,L, Aranda,P, Llopis,J] Biomedical Research Centre (CIBM), Sport and Health Research Centre (IMUDs), Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Granada, Spain. [Rodríguez-Nogales,A, Algieri,F] CIBERehd, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Department of Pharmacology, CIBM, University of Granada, Granada, Spain. [Montes-Bayón,M] Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Oviedo, Spain, We are grateful for the support received from the Consejería de Innovación, Ciencia y Empresa, Andalusian Regional Government (Project P06-CTS-01435), and from the Spanish Ministry of Economy and Competitivity (SAF2011-29648), the CIBERehd is funded by the Instituto de Salud Carlos III. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Anatomy::Digestive System::Liver [Medical Subject Headings] Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation [Medical Subject Headings] Chemicals and Drugs::Inorganic Chemicals::Minerals [Medical Subject Headings] Hepcidin Vanadio Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Iron-Regulatory Proteins::Hepcidins [Medical Subject Headings] Intestinal absorption Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Gene expression Organisms::Eukaryota::Animals [Medical Subject Headings] Intestinal Mucosa Whole blood Nutrition and Dietetics biology diabetes Diabetes Anemia anemia Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus Experimental [Medical Subject Headings] Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Control Groups [Medical Subject Headings] medicine.symptom Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Anemia [Medical Subject Headings] lcsh:Nutrition. Foods and food supply Hierro medicine.medical_specialty mRNA Iron Inflammation lcsh:TX341-641 Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings] Streptozocin Article Diabetes Mellitus Experimental 03 medical and health sciences Ratas Hepcidins Internal medicine Diabetes mellitus Chemicals and Drugs::Inorganic Chemicals::Elements::Metals Heavy::Iron [Medical Subject Headings] medicine Animals Humans Hypoglycemic Agents RNA Messenger Absorción intestinal Chemicals and Drugs::Hormones Hormone Substitutes and Hormone Antagonists::Hormones::Peptide Hormones::Pancreatic Hormones::Insulins [Medical Subject Headings] 030102 biochemistry & molecular biology Inflamación business.industry ARN mensajero Chemicals and Drugs::Organic Chemicals::Nitroso Compounds::Nitrosourea Compounds::Streptozocin [Medical Subject Headings] Vanadium Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleic Acids::RNA::RNA Messenger [Medical Subject Headings] medicine.disease Rats rats Insulin receptor Chemicals and Drugs::Inorganic Chemicals::Elements::Metals Heavy::Vanadium [Medical Subject Headings] 030104 developmental biology Endocrinology Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats [Medical Subject Headings] Gene Expression Regulation Intestinal Absorption inflammation biology.protein vanadium Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hypoglycemic Agents [Medical Subject Headings] hepcidin business Phenomena and Processes::Metabolic Phenomena::Metabolism::Absorption::Intestinal Absorption [Medical Subject Headings] Anatomy::Digestive System::Gastrointestinal Tract::Intestines::Intestinal Mucosa [Medical Subject Headings] Food Science Expresión génica |
| Zdroj: | Nutrients, Vol 13, Iss 1256, p 1256 (2021) Nutrients Scopus RUO. Repositorio Institucional de la Universidad de Oviedo instname Digibug: Repositorio Institucional de la Universidad de Granada Universidad de Granada (UGR) Digibug. Repositorio Institucional de la Universidad de Granada Volume 13 Issue 4 |
| Popis: | We are grateful for the support received from the Consejeria de Innovacion, Ciencia y Empresa, Andalusian Regional Government (Project P06-CTS-01435), and from the Spanish Ministry of Economy and Competitivity (SAF2011-29648); the CIBERehd is funded by the Instituto de Salud Carlos III. This paper forms part of the Doctoral Program in Nutrition and Food Science of the University of Granada. Diabetes is a disease with an inflammatory component that courses with an anemic state. Vanadium (V) is an antidiabetic agent that acts by stimulating insulin signaling. Hepcidin blocks the intestinal absorption of iron and the release of iron from its deposits. We aim to investigate the effect of V on hepcidin mRNA expression and its consequences on the hematological parameters in streptozotocin-induced diabetic Wistar rats. Control healthy rats, diabetic rats, and diabetic rats treated with 1 mgV/day were examined for five weeks. The mineral levels were measured in diet and serum samples. Hepcidin expression was quantified in liver samples. Inflammatory and hematological parameters were determined in serum or whole blood samples. The inflammatory status was higher in diabetic than in control rats, whereas the hematological parameters were lower in the diabetic rats than in the control rats. Hepcidin mRNA expression was significantly lower in the V-treated diabetic rats than in control and untreated diabetic rats. The inflammatory status remained at a similar level as the untreated diabetic group. However, the hematological profile improved after the V-treatment, reaching similar levels to those found in the control group. Serum iron level was higher in V-treated than in untreated diabetic rats. We conclude that V reduces gene expression of hepcidin in diabetic rats, improving the anemic state caused by diabetes. Consejeria de Innovacion, Ciencia y Empresa, Andalusian Regional Government P06-CTS-01435 Spanish Ministry of Economy and Competitivity SAF2011-29648 Instituto de Salud Carlos III European Commission |
| Databáze: | OpenAIRE |
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