Can membrane progesterone receptor on T regulatory cells explainthe ensuing human labour?
| Autor: | Paulo Rodrigues-Santos, Manuel Santos-Rosa, Sofia Vale-Pereira, Anabela Mota-Pinto, Ana Luísa Areia, Paulo Moura, Vera Alves |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Labour Immunology chemical and pharmacologic phenomena Tregs Normal pregnancy Third trimester Treg cell T-Lymphocytes Regulatory Flow cytometry 03 medical and health sciences Immune system Pregnancy Internal medicine medicine Immunology and Allergy Humans Progesterone Labor Obstetric mPRalpha medicine.diagnostic_test business.industry Cell Membrane Obstetrics and Gynecology hemic and immune systems medicine.disease Flow Cytometry Membrane progesterone receptor 030104 developmental biology Endocrinology Reproductive Medicine T cell subset Female business Receptors Progesterone |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| Popis: | Progesterone acts as an immunosteroid by contributing to the establishment of a pregnancy-protective milieu. It seems that it is the responsibility of progesterone to evade the inflammatory events that lead to parturition. T regulatory lymphocytes (Treg cells) could further explain the inhibition of the inflammatory mechanisms that lead to labour through the rapid action of progesterone on this cell subset. We investigated Treg cells and the membrane progesterone receptor α (mPRα) in these immune cells with in relationship to human parturition. This pilot cohort study was conducted in a single-centre tertiary obstetrical unit with 20 normal pregnant women. Variation in the absolute and relative frequency of CD4(+) T cells, Treg cells, and of mPR(α+) Treg cells was calculated by flow cytometry on three occasions (second and third trimesters; delivery day). Our results show that during normal pregnancy there is a generalised increase in Treg cells and mPR(α+) Treg cells, from the second to the third trimesters (23.4% vs. 52.3% and 4.3% vs. 8.3%, respectively). On the contrary, on delivery day, compared with the values in the third trimester, there is a sudden decrease in both Treg cells (52.3% vs. 17.4%) and mPR(α+) Treg cells (8.3% vs. 6.1%). Our findings suggest that human labour may develop as a consequence of a decline in mPR(α+) Treg cells, which reduces progesterone anti-inflammatory action through Treg cells. |
| Databáze: | OpenAIRE |
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