The development of a febrile response to pyrogen in the thyroid-deficient rabbit
| Autor: | I. R. Pela, Marcos Macari, C. A A Silva |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Lipopolysaccharides
Male medicine.medical_specialty Fever Lipopolysaccharide Physiology medicine.medical_treatment Body Temperature chemistry.chemical_compound Hypothyroidism Pharmacokinetics Physiology (medical) Internal medicine medicine Animals Endocrine system New zealand white Pharmacology Pyrogens business.industry Thyroid Thyroidectomy Rabbit (nuclear engineering) General Medicine Propranolol Endocrinology medicine.anatomical_structure chemistry Propylthiouracil Rabbits business medicine.drug |
| Zdroj: | Universidade Estadual Paulista "Júlio de Mesquita Filho" |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/y87-209 |
| Popis: | The development of the febrile response to E. coli lipopolysaccharide (1.5 micrograms/kg, i.v.) in thyroid-deficient rabbits has been studied. Twenty-eight New Zealand White rabbits weighing 2.1-2.3 kg were used. Hypothyroidism was induced by treatment with propylthiouracil (100 or 200 mg/kg body wt./15 days). Thyroid-deficient animals showed a reduction in the febrile response to lipopolysaccharide, but the effect was significantly different (p less than 0.01) from the control only for rabbits treated with 200 mg/kg of propylthiouracil. Propranolol (2 mg/kg, i.p.) given 30 min before lipopolysaccharide also reduced (p less than 0.01) the fever response in control rabbits. The results of this experiment are consistent with the hypothesis that the reduction in the febrile response of thyroid-deficient rabbits is due to the reduced number of beta-adrenergic receptors, or to a change in the availability of neurotransmitter in thermogenically active tissues, such as brown fat. |
| Databáze: | OpenAIRE |
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