Association between variants in vitamin D‐binding protein gene and vitamin D deficiency among pregnant women in china
Autor: | Jinju Dong, Ting Wang, Yi Mi, Congli Liu, Yangqing Lu, Fei Li, Lingyun Wang, Jun Li, Lijun Wang, Hongmei Zhou, Qinghong Zhou, Wang-Yang Xu, Jinxiu Wang, Peng Meng, Jie Deng, Juan Wang |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Microbiology (medical) Adult medicine.medical_specialty China Vitamin D-binding protein Clinical Biochemistry SNP Single-nucleotide polymorphism Polymorphism Single Nucleotide vitamin D deficiency 03 medical and health sciences Young Adult 0302 clinical medicine Pregnancy Internal medicine Genotype medicine Vitamin D and neurology Immunology and Allergy Humans Vitamin D Gene Genotyping Research Articles 25(OH)D business.industry Vitamin D-Binding Protein Biochemistry (medical) Public Health Environmental and Occupational Health Infant Hematology medicine.disease Vitamin D Deficiency Pregnancy Complications Medical Laboratory Technology 030104 developmental biology Endocrinology birthweight 030220 oncology & carcinogenesis Dietary Supplements Female business pregnant women Research Article |
Zdroj: | Journal of Clinical Laboratory Analysis |
ISSN: | 1098-2825 0887-8013 |
Popis: | Background The prevalence of vitamin D deficiency and insufficiency is extremely high in pregnant women worldwide. However, the association between single nucleotide polymorphisms (SNPs) in vitamin D metabolic pathway genes and 25‐hydroxyvitamin D (25(OH)D) concentration among Chinese pregnant women is seldom reported. The risk of adverse neonatal outcomes due to maternal vitamin D deficiency has not been well investigated. Methods A total of 815 pregnant women and 407 infants were enrolled in this study. Serum 25(OH)D concentration was detected. DNA was extracted from the maternal blood for genotyping genetic SNPs in vitamin D pathway. An XGBoost model was established based on SNPs combined with external variables. Results Mean serum 25(OH)D level was 15.67 ± 7.98 ng/mL among the pregnant women. Seventy‐five percent of pregnant women had 25(OH)D deficiency in China. SNPs of GC (rs17467825, rs4588, rs2282679, rs2298850, and rs1155563) were significantly associated with maternal 25(OH)D concentration. The influence of variants of rs17467825, rs4588, rs2282679, and rs2298850 on maternal 25(OH)D might be modified by vitamin D supplementation and sunshine exposure. An XGBoost model was established for monitoring 25(OH)D status in pregnant women and provided clinical advice to reduce the risk of 25(OH)D deficiency. Mothers with 25(OH)D deficiency hinted a risk for macrosomia. Conclusion A high prevalence of vitamin D deficiency in China has been confirmed. A clinical model was established to guide pregnant women to supplement vitamin D according to genotype. Furthermore, we suggest the effect of maternal vitamin D status on the risk of macrosomia. |
Databáze: | OpenAIRE |
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