Genetic characterization of Plasmodium falciparum allelic variants infecting mothers at delivery and their children during their first plasmodial infections
| Autor: | Bich-Tram Huynh, Natacha Martin, C. Pierrat, Claude Ahouangninou, Florence Migot-Nabias, Violeta Moya Alvarez, Rodolphe Ladekpo, André Garcia, Emmanuelle Renard, Célia Dechavanne, Bruno Costes |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Microbiology (medical) Permissiveness Placenta Diseases Offspring Placenta Plasmodium falciparum Protozoan Proteins Antigens Protozoan Biology Polymorphism Single Nucleotide Microbiology Immune tolerance Antigen Pregnancy parasitic diseases Genetics medicine Humans Malaria Falciparum Pregnancy Complications Infectious Allele Molecular Biology Alleles Ecology Evolution Behavior and Systematics Infant Newborn Genetic Variation Infant Sequence Analysis DNA DNA Protozoan medicine.disease biology.organism_classification Virology Infectious Disease Transmission Vertical Infectious Diseases In utero Immunology Female Malaria |
| Zdroj: | Infection, Genetics and Evolution. 20:16-25 |
| ISSN: | 1567-1348 |
| DOI: | 10.1016/j.meegid.2013.07.026 |
| Popis: | Introduction Infants born to mothers with placental malaria at delivery develop Plasmodium falciparum parasitemia earlier than those born to mothers without placental infection. This phenomenon may be explained by the development of immune tolerance due to exposure to P. falciparum antigens in utero. The hypothesis of this study is that this increased susceptibility might be related to infections by parasites expressing the same blood stage allele’s antigens as those to which the infants were exposed in utero. Methods The comparison of P. falciparum msp2 (3D7 and FC27) and glurp gene polymorphisms of infected mothers at delivery to those of their offspring’s infections during infancy was realized and the possible associations of the different polymorphisms with clinical outcomes were assessed. A second approach consisted in the use of a Geographic Information System to determine whether the antigen alleles were homogeneously distributed in the area of study. This was necessary to analyze whether the biological observations were due to high exposure to a particular antigen allelic form in the environment or to high infant permissiveness to the same allelic antigen polymorphism as the placental one. Results Infants born to mothers with placental malaria at delivery were more susceptible to infections by parasites carrying the same glurp allele as encountered in utero compared to distinct alleles, independently of their geographic distribution. Conclusion The increased permissiveness of infants to plasmodial infections with shared placental-infant glurp alleles sheds light on the role that P. falciparum blood stage antigen polymorphisms may play in the first plasmodial infections in infancy. |
| Databáze: | OpenAIRE |
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