An assessment of differences in costs and health benefits of serology and NAT screening of donations for blood transfusion in different Western countries

Autor: Janssen, M. P., van Hulst, M., Custer, B., Bennett, Judie Leach, McDonald, Peter, Menitove, Jay, Tomasulo, Peter, Viner, Tina, Ward, Sheila, Brailsford, Su, Chu, Kwei, Georgsen, Jørgen, Hansen, Morten Bagge, Heney, Patrick, Keller, Anthony, Krusius, Tom, Marsh, Daniel C., Nyberg-Oksanen, Eeva, O'Brien, Sheila, Prunier, Nina, Stramer, Susan L., Tiberghien, Pierre, van Weert, Anton
Jazyk: angličtina
Rok vydání: 2017
Předmět:
medicine.medical_specialty
Blood transfusion
TRANSMISSION
Blood Safety
Cost-Benefit Analysis
medicine.medical_treatment
Population
Psychological intervention
Blood Donors
HIV Infections
UNCERTAINTY
030204 cardiovascular system & hematology
DECISION-MAKING
HEPATITIS-C VIRUS
RELATIVE EFFICACY
Serology
03 medical and health sciences
0302 clinical medicine
Environmental health
Humans
Mass Screening
Medicine
health economics
Blood Transfusion
030212 general & internal medicine
education
cost-utility
RISK
education.field_of_study
INTERNATIONAL REGIONS
Health economics
Cost–benefit analysis
business.industry
MEDICINE
Blood Screening
blood screening
international comparison
Hematology
General Medicine
Hepatitis B
Hepatitis C
Quality-adjusted life year
Surgery
ECONOMIC EVALUATIONS
SAFETY
Quality-Adjusted Life Years
business
Zdroj: Vox Sanguinis, 112(6), 518. Wiley-Blackwell
Vox Sanguinis, 112(6), 518-525. Wiley
ISSN: 0042-9007
Popis: Background and Objectives The cost-utility of safety interventions is becoming increasingly important as a driver of implementation decisions. The aim of this study was to compare the cost-utility of different blood screening strategies in various settings, and to analyse the extent and cause of differences in health economic results.Materials and Methods For eight Western countries (Australia, Canada, Denmark, Finland, France, The Netherlands, UK and the United States of America), data were collected on donor and recipient populations, blood products, screening tests, and on patient treatment practices and costs. An existing ISBT web-tool model was used to assess the cost-utility of various strategies for HIV, HCV and HBV screening.Results The cost-utility ratio of serology screening for these eight countries ranges between -11 000 and 92 000 US$ per QALY, and for NAT between -12 000 and 113 000 US$ per QALY when compared to no screening. Combined serology and NAT ranges between 600 and 217 000 US$ per QALY. The incremental cost-utility of NAT after implementation of serology screening ranges from 2 231 000 to 15 778 000 US$ per QALY.Conclusion There are substantial differences in costs per QALY between countries for various HIV, HBV and HCV screening strategies. These differences are primarily caused by costs of screening tests and infection rates in the donor population. Within each country, similar cost per QALY results for serology and NAT compared to no screening, coupled with evidence of limited value of serology and NAT together prompts the need for further discussion on the acceptability of parallel testing by serology and NAT.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje