Expression of cytokines following vaccination of goats with a recombinant capripoxvirus vaccine expressing Rift Valley fever virus proteins

Autor: Emna Ayari-Fakhfakh, Catherine Cetre-Sossah, Abdeljelil Ghram, Emmanuel Albina
Přispěvatelé: Institut de Recherche Vétérinaire de Tunisie (IRVT), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP), Université Tunis El Manar (UTM), Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA), This study was partially funded by the French Minsitry of European and Foreign Affairs (FSP project N°2003-24 'LABOVET')., We wish to acknowledge N. Richard, T. Macotta, C. Le Goff, O. Kwiatek, P. Totté and M. Jego for their technical assistance and G. Libeau for her expertise on PPR., Université de Tunis El Manar (UTM), Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
viruses
animal diseases
Antibodies
Viral
L73 - Maladies des animaux
Capripoxvirus
MESH: Viral Vaccines/genetics
MESH: Antibodies
Viral/blood
0302 clinical medicine
Immunogenicity
Vaccine
Viral Envelope Proteins
MESH: Vaccination/veterinary
MESH: Recombinant Proteins/immunology
MESH: Animals
MESH: Cytokines/immunology
Rift Valley fever
Neutralizing antibody
Immunogenicity
Goats
Vaccination
MESH: Immunogenicity
Vaccine
Recombinant Proteins
3. Good health
medicine.anatomical_structure
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
MESH: Viral Envelope Proteins/immunology
Cytokines
MESH: Rift Valley fever virus
030231 tropical medicine
Immunology
MESH: Antibodies
Neutralizing/blood
Biology
MESH: Goats
03 medical and health sciences
Immune system
Immunity
medicine
Animals
Immune response
B cell
MESH: Rift Valley Fever/prevention & control
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
General Veterinary
MESH: Capripoxvirus
Viral Vaccines
MESH: Viral Vaccines/immunology
MESH: Rift Valley Fever/immunology
biology.organism_classification
medicine.disease
Rift Valley fever virus
Virology
Antibodies
Neutralizing
030104 developmental biology
biology.protein
Zdroj: Veterinary Immunology and Immunopathology
Veterinary Immunology and Immunopathology, Elsevier, 2018, 197, pp.15--20. ⟨10.1016/j.vetimm.2018.01.001⟩
ISSN: 0165-2427
DOI: 10.1016/j.vetimm.2018.01.001⟩
Popis: International audience; The mosquito-borne Rift Valley fever virus (RVFV) causes severe diseases in domesticated animals including cattle, sheep, camels and goats. Capripoxviruses (CPV) are suitable vectors for multivalent vaccine development. A recombinant rKS1-based CPV expressing the gene encoding the viral glycoprotein Gn of RVFV has been shown to induce protection in mice and sheep. The aim of this study was to evaluate the immunogenicity induced by this candidate vaccine in goats, and the level of cytokines produced by RVFV-specific Th1 and Th2 lymphocytes. The results of this study suggest that Th2 mediates immunity mainly through the significant production of IL4, which, coupled with a decrease in IFN-γ, may be involved in the replication of the capripoxvirus expressing the GN of RVFV. CD4+ cells may play the role of helper cells in B cell responses and neutralizing antibody production in the anti-CPV humoral response, leading to strong immunity against RVFV.
Databáze: OpenAIRE
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