Prospective longitudinal investigation shows correlation of event-related potential to mild traumatic brain injury in adolescents
| Autor: | Amir B. Geva, Offir Laufer, Amit Reches, Jeffrey S. Kutcher, Yaki Stern, Maayan Ettinger, Todd Arthur, Kim D. Barber Foss, Gregory D. Myer, Jonathan D. Ellis |
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| Rok vydání: | 2020 |
| Předmět: |
030506 rehabilitation
medicine.medical_specialty Adolescent Traumatic brain injury Adolescent athletes Neuroscience (miscellaneous) Correlation 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Event-related potential Concussion Developmental and Educational Psychology medicine Humans Longitudinal Studies Prospective Studies Longitudinal cohort Evoked Potentials Brain Concussion business.industry Electroencephalography medicine.disease Neurology (clinical) 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | Brain injury. 34(7) |
| ISSN: | 1362-301X |
| Popis: | Prospective longitudinal cohort study.Adolescent athletes may be more susceptible to the long-term effects of mild traumatic brain injury (mTBI). A diagnostic and prognostic neuromarker may optimize management and return-to-activity decision-making in athletes who experience mTBI.Measure an event-related potential (ERP) component captured with electroencephalography (EEG), called processing negativity (PN), at baseline and post-injury in adolescents who suffered mTBI and determine their longitudinal response relative to healthy controls.Thirty adolescents had EEG recorded during an auditory oddball task at a pre-mTBI baseline session and subsequent post-mTBI sessions. Longitudinal EEG data from patients and healthy controls (n= 77) were obtained from up to four sessions in total and processed using Brain Network Analysis algorithms.The average PN amplitude in healthy controls significantly decreased over sessions 2 and 3; however, it remained steady in the mTBI group's 2nd (post-mTBI) session and decreased only in sessions 3 and 4. Pre- to post-mTBI amplitude changes correlated with the time interval between sessions.These results demonstrate that PN amplitude changes may be associated with mTBI exposure and subsequent recovery in adolescent athletes. Further study of PN may lead to it becoming a neuromarker for mTBI prognosis and return-to-activity decision-making in adolescents. |
| Databáze: | OpenAIRE |
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