FT-IR Spectroscopy for the Detection of Diethylene Glycol (DEG) Contaminant in Glycerin-Based Pharmaceutical Products and Food Supplements
| Autor: | Eman Kh Abboushi, Ayman Hammoudeh, Amal Mahmoud, Safwan M. Obeidat |
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| Rok vydání: | 2020 |
| Předmět: |
Detection limit
diethylene glycol (deg) glycerin Chromatography Diethylene glycol Fraction (chemistry) Quantitative determination pharmaceutical products lcsh:Chemistry Absorbance food supplements chemistry.chemical_compound lcsh:QD1-999 chemistry Ft ir spectroscopy General Earth and Planetary Sciences Fourier transform infrared spectroscopy Spectroscopy ft-ir General Environmental Science |
| Zdroj: | Acta Chimica Slovenica, Vol 67, Iss 2, Pp 530-536 (2020) |
| ISSN: | 1580-3155 |
| Popis: | Identification and determination of diethylene glycol (DEG) in glycerin-based products was successfully achieved using FT-IR spectroscopy. Studied samples included 0.5% to 20% by mass DEGspiked into cough syrup, two paracetamol syrup formulations, and two food supplements. The characteristic DEGwavenumbers at 881 cm -1 and 1083 cm -1 were used for its quantitative determination in the studied samples. A very good accuracy in determining the DEG fraction was achieved with a mean error% of ±2.02% to ±7.69% upon using the corrected absorbance at 881 cm -1 . The corrected absorbance at 1083 cm -1 band was used in the case of paracetamol formulations and resulted in a mean error% ranging from ±2.50% to ±10.28%. The values of limit of detection of the current method ranged from 0.051% to 0.068% DEG for all studied samples. |
| Databáze: | OpenAIRE |
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