Alterations in the antioxidant defense system in prepubertal children with a history of extrauterine growth restriction
| Autor: | Mercedes Gil-Campos, María D. Mesa, Cruz E. Garcia-Rodriguez, J. L. Pérez-Navero, M. Ortiz-Espejo, María Carmen Muñoz-Villanueva |
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| Rok vydání: | 2013 |
| Předmět: |
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medicine.medical_specialty Erythrocytes Antioxidant medicine.medical_treatment alpha-Tocopherol Glutathione reductase Nutritional Status Medicine (miscellaneous) Intrauterine growth restriction Gestational Age Biology medicine.disease_cause Antioxidants Superoxide dismutase chemistry.chemical_compound Internal medicine medicine Birth Weight Humans Child Vitamin A Growth Disorders chemistry.chemical_classification Glutathione Peroxidase Nutrition and Dietetics Superoxide Dismutase Glutathione peroxidase Infant Newborn Retinol Catalase beta Carotene medicine.disease Oxidative Stress Glutathione Reductase Endocrinology chemistry Case-Control Studies Child Preschool Prepubertal stage biology.protein Female Biomarkers Infant Premature Oxidative stress |
| Zdroj: | European Journal of Nutrition. 53:607-615 |
| ISSN: | 1436-6215 1436-6207 |
| Popis: | The role of oxidative stress is well known in the pathogenesis of acquired malnutrition. Intrauterine growth restriction has been associated with an imbalance in oxidative stress/antioxidant system. Therefore, early postnatal environment and, consequently, extrauterine growth restriction might be associated with alterations in the antioxidant defense system, even in the prepubertal stage. This is a descriptive, analytical, and observational case–control study. The study included two groups; 38 Caucasian prepubertal children born prematurely and with a history of extrauterine growth restriction as the case group, and 123 gender- and age-matched controls. Plasma exogenous antioxidant (retinol, β-carotene, and α-tocopherol) concentrations were measured by HPLC; antioxidant enzyme activities of catalase, glutathione reductase, glutathione peroxidase, and superoxide dismutase were determined in lysed erythrocytes by spectrophotometric techniques. Catalase and glutathione peroxidase concentrations were significantly lower in extrauterine growth restriction children than in controls (P |
| Databáze: | OpenAIRE |
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