Both Low and High Serum IGF-1 Levels Associate With Increased Risk of Cardiovascular Events in Elderly Men
| Autor: | Max Petzold, Daniel Carlzon, Dan Mellström, Claes Ohlsson, Johan Svensson, Åsa Tivesten, Magnus Karlsson, Östen Ljunggren |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Risk medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Population Context (language use) Hot Topics in Translational Endocrinology Biochemistry Endocrinology Internal medicine Prevalence medicine Humans Prospective Studies Registries Insulin-Like Growth Factor I education Prospective cohort study Aged Aged 80 and over Sweden education.field_of_study Proportional hazards model business.industry Incidence Incidence (epidemiology) Biochemistry (medical) Hazard ratio Confidence interval Cardiovascular Diseases Cohort business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 99:E2308-E2316 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2014-1575 |
| Popis: | Context: Most previous prospective studies suggest that low serum IGF-1 associates with increased risk of cardiovascular disease (CVD) events whereas other studies suggest that high serum IGF-1 associates with increased risk of CVD events. Objective: We tested the hypothesis that not only low, but also high serum IGF-1 levels associate with increased risk of CVD events in elderly men. Setting and Design: Serum IGF-1 levels were measured in 2901 elderly men (age 69–81 years) included in the Swedish cohort of the prospective, population-based Osteoporotic Fractures in Men Study (MrOS), Sweden cohort. Data for CVD events were obtained from national Swedish registers with no loss of followup. Results: During followup (median, 5.1 y) 589 participants experienced a CVD event. The association between serum IGF-1 and risk of CVD events was nonlinear, and restricted cubic spline Cox regression analysis revealed a U-shaped association between serum IGF-1 levels and CVD events (P < .01 for nonlinearity). Low as well as high serum IGF-1 (quintile 1 or 5 vs quintiles 2–4) significantly associated with increased risk for CVD events (hazard ratio [HR] = 1.25, 95% confidence interval, [CI], 1.02–1.54; and HR = 1.35, 95% CI 1.10–1.66, respectively). These associations remained after adjustment for prevalent CVD and multiple risk factors. High serum IGF-1 associated with increased risk of coronary heart disease (CHD) events but not with risk of cerebrovascular events. Conclusions: Both low and high serum IGF-1 levels are risk markers for CVD events in elderly men. The association between high serum IGF-1 and CVD events is mainly driven by CHD events. |
| Databáze: | OpenAIRE |
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