Increased Fecal Calprotectin is Associated with Worse Gastrointestinal Symptoms and Quality of Life Scores in Children with Cystic Fibrosis
| Autor: | Fabien Beaufils, Michael Fayon, Raphaël Enaud, Stéphanie Bui, Laurence Delhaes, Thierry Lamireau, Emmanuel Mas, H. Clouzeau, François Galode, M. Mittaine, Martin Addra |
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| Přispěvatelé: | Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Aquitaine’s Care and Research organisation for inflammatory and Immune-Mediated diseases [CHU Bordeaux] (FHU ACRONIM), CHU Bordeaux [Bordeaux], CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche en Santé Digestive (IRSD ), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Toulouse [Toulouse], Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Admin, Oskar, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Nausea lcsh:Medicine Gastroenterology Cystic fibrosis [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract Article 03 medical and health sciences 0302 clinical medicine Bloating [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics Quality of life 030225 pediatrics Internal medicine gas intestinal inflammation Medicine [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics business.industry lcsh:R [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology General Medicine pancreatic insufficiency medicine.disease nausea [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology humanities 3. Good health [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie Vomiting Biomarker (medicine) [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract 030211 gastroenterology & hepatology [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie reflux Calprotectin medicine.symptom business Dysbiosis |
| Zdroj: | Journal of Clinical Medicine, Vol 9, Iss 4080, p 4080 (2020) Journal of Clinical Medicine Journal of Clinical Medicine, MDPI, 2020, 9 (12), ⟨10.3390/jcm9124080⟩ Journal of Clinical Medicine, 2020, 9 (12), ⟨10.3390/jcm9124080⟩ Volume 9 Issue 12 |
| ISSN: | 2077-0383 |
| Popis: | In cystic fibrosis (CF), cystic fibrosis transmembrane regulator (CFTR) dysfunction leads to digestive disorders that promote intestinal inflammation and dysbiosis enhancing gastrointestinal symptoms. In pancreatic insufficiency CF patients, both intestinal inflammation and dysbiosis, are associated with an increase in the fecal calprotectin (FC) level. However, associations between the FC level, gastrointestinal symptoms, and quality of life (QoL) remain poorly studied. We aimed to assess such associations in pancreatic insufficiency CF children. The FC level was measured in pancreatic insufficiency CF children&rsquo s stool samples. Children and their parents completed two questionnaires: The Gastrointestinal Symptoms Scales 3.0-PedsQLTM and the Quality of Life Pediatric Inventory 4.0-PedsQLTM. Lower scores indicated worse symptomatology or QoL. Thirty-seven CF children were included. A FC level above 250 µ g/g was associated with worse gastrointestinal symptoms and QoL scores. The FC level was inversely correlated with several gastrointestinal scores assessed by children (i.e., Total, &ldquo Heart Burn Reflux&rdquo &ldquo Nausea and Vomiting&rdquo and &ldquo Gas and Bloating&rdquo ). Several QoL scores were correlated with gastrointestinal scores. The FC level was weakly associated with clinical parameters. Some gastrointestinal and QoL scores were related to disease severity associated parameters. In CF, the FC level, biomarker previously related to intestinal inflammation and dysbiosis, was associated with worse digestive symptoms and QoL scores. |
| Databáze: | OpenAIRE |
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