Impact of chemotherapy-induced amenorrhea in breast cancer patients: the evaluation of ovarian function by menstrual history and hormonal levels
| Autor: | Kexin Meng, Wei Tian, Meiqi Zhou, Hailong Chen, Yongchuan Deng |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Adult
medicine.medical_specialty Antineoplastic Agents Hormonal Breast Neoplasms Menstruation Follicle-stimulating hormone Breast cancer Internal medicine medicine Chemotherapy-induced amenorrhea Humans Adverse effect Amenorrhea Ovarian Function Tests Retrospective Studies Gynecology Estradiol business.industry Incidence (epidemiology) Research Middle Aged medicine.disease Prognosis Hormones Menopause Tamoxifen Oncology Chemotherapy Adjuvant Female Surgery medicine.symptom business medicine.drug Follow-Up Studies |
| Zdroj: | World Journal of Surgical Oncology |
| ISSN: | 1477-7819 |
| DOI: | 10.1186/1477-7819-11-101 |
| Popis: | Background Chemotherapy-induced amenorrhea (CIA) is one of the most frequent therapy-related adverse events observed in breast cancer patients who have undergone chemotherapy. Although the characteristics of CIA have been studied in Western countries, little is known about CIA in Asian. We conducted a retrospective analysis to assess the characteristics and influencing factors of CIA and its association with menopause in Chinese women who underwent adjuvant chemotherapy for early-stage breast cancer. Methods Seventy-three premenopausal women who underwent adjuvant chemotherapy for early stage (stages I to III) breast cancer were analyzed. Patient clinical characteristics, treatment regimes, menstrual information, and serum hormone values were collected retrospectively. Characteristic factors relevant to the onset of CIA and menopause were also estimated. Results Approximately 83.6% of patients developed CIA. Older patients (>40 years old) had higher CIA incidence compared with younger patients (P P P = 0.0313). On the basis of the Kaplan–Meier analysis, a significant difference was observed in the time of onset of permanent amenorrhea as determined by menstrual history and hormone levels (P = 0.0028). In women aged 46 to 49 years, the beginning of permanent amenorrhea was detected earlier via the clinical method than via the hormonal method (2 months versus 23 months, P P = 0.0112). Conclusions Age at diagnosis is a predictor of the onset of amenorrhea and transformation into menopause among premenopausal breast cancer patients. Adjuvant tamoxifen therapy substantially affects the onset of menopause. A delay of the onset of serum hormone postmenopausal status was observed compared with clinical symptoms. This interval was approximately 21 months in patients aged 46 to 49 years and 17 months in patients aged over 50 years. This interval is significant in the clinical estimate of the menstrual status. |
| Databáze: | OpenAIRE |
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