Intra-individual and inter-individual variations in sperm aneuploidy frequencies in normal men
| Autor: | Bernard Robaire, Renée H. Martin, Alfred Rademaker, Helen G. Tempest, E. Ko, Peter T.K. Chan |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Adolescent Aneuploidy Semen Biology Andrology Young Adult Nondisjunction Genetic Reference Values medicine Humans Prospective cohort study In Situ Hybridization Fluorescence Chromosome Aberrations Genetics Chromosomes Human X Chromosomes Human Y medicine.diagnostic_test Genetic Variation Obstetrics and Gynecology Chromosome Uniparental Disomy medicine.disease Spermatozoa Sperm Reproductive Medicine Nondisjunction Ploidy Fluorescence in situ hybridization |
| Zdroj: | Fertility and Sterility. 91:185-192 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/j.fertnstert.2007.11.002 |
| Popis: | Objective To investigate whether there are intra-individual and/or inter-individual variations in sperm aneuploidy frequencies within the normal male population, and, if this is the case, whether they are sporadic or time-stable variants. Design Prospective study. Setting University research laboratory. Patient(s) Ten men aged 18–32 years. Intervention(s) None. Main Outcome Measure(s) Fluorescence in situ hybridization was used to investigate sperm aneuploidy frequencies for chromosomes X, Y, 13, and 21 in serial semen samples collected over a period of 12–18 months. Result(s) Intra-individual and inter-individual variations were investigated by comparing serial samples from the same donor and by comparing the donors with each other, respectively. Intra-individual variations were found in all 10 donors for at least one investigated chromosome; variations tended to be sporadic events affecting only one time point. Inter-individual variations were found for all chromosomes (except XX and YY disomy and disomy 21), with three men identified as stable variants, consistently producing higher levels of aneuploidy for at least one of the following aneuploidies: sex chromosome nullisomy; disomy 13, or diploidy. Conclusion(s) These results suggest that there are a number of factors and mechanisms that have the potential to sporadically or consistently affect sperm aneuploidy. |
| Databáze: | OpenAIRE |
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