Adverse drug events in a paediatric intensive care unit: a prospective cohort
| Autor: | Eduardo Juan Troster, Orlei Ribeiro de Araujo, Audrey Rie Ogawa Shibata, Dafne Cardoso Bourguignon da Silva, Rodrigo Genaro Arduini, Carolina Figueira Rabello Alonso |
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| Rok vydání: | 2013 |
| Předmět: |
Drug
medicine.medical_specialty Pediatrics business.industry Research media_common.quotation_subject Intensive Care Psychological intervention General Medicine Logistic regression Intensive care unit law.invention Paediatric intensive care unit law Intensive care Emergency medicine medicine Observational study Prospective cohort study business media_common |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| DOI: | 10.1136/bmjopen-2012-001868 |
| Popis: | Objectives: To describe adverse drug events (ADEs) in children under intensive care, identify risk factors and tools that can detect ADEs early, and the impact on length of stay (LOS). Design: A prospective observational study. Setting: Paediatric intensive care unit of a tertiary care teaching hospital. Patients: 239 patients with a mean age of 67.5 months representing 1818 days of hospitalisation in intensive care unit. Interventions: Active search of charts and electronic patient records using triggers. The statistical analysis involved linear and logistic regression. Measurements and main results: The average LOS was 7.6 days. There were 110 proven, probable and possible ADEs in 84 patients (35.1%). We observed 138 instances of triggers. The major classes of drugs associated with events were: antibiotics (n=41), diuretics (n=24), antiseizures (n=23), sedatives and analgesics (n=17) and steroids (n=18). The number of drugs administered was most related to the occurrence of ADEs and also to the LOS (p |
| Databáze: | OpenAIRE |
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