Venous thromboembolism in epithelial ovarian cancer. A prospective cohort study
Autor: | Ole Bjarne Christiansen, Aage Knudsen, Anni Grove, Ole Thorlacius-Ussing, Christian Torp-Pedersen, Victor Vishwanath Iyer, Henriette Strøm Kahr |
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Rok vydání: | 2019 |
Předmět: |
Thorax
medicine.medical_specialty endocrine system diseases Deep vein Carcinoma Ovarian Epithelial 030204 cardiovascular system & hematology Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Outpatient clinic Cumulative incidence Prospective Studies cardiovascular diseases Prospective cohort study Aged business.industry Incidence (epidemiology) Pulmonary embolism Venous Thromboembolism Hematology Epithelial ovarian cancer Middle Aged equipment and supplies medicine.disease Thrombosis female genital diseases and pregnancy complications medicine.anatomical_structure 030220 oncology & carcinogenesis Deep venous thrombosis Female business Venous thromboembolism |
Zdroj: | Kahr, H S, Christiansen, O B, Grove, A, Iyer, V V, Torp-Pedersen, C, Knudsen, A & Thorlacius-Ussing, O 2019, ' Venous thromboembolism in epithelial ovarian cancer : A prospective cohort study ', Thrombosis Research, vol. 181, pp. 112-119 . https://doi.org/10.1016/j.thromres.2019.07.027 |
ISSN: | 0049-3848 |
Popis: | Objective To determine the incidence of symptomatic and incidental venous thromboembolism (VTE) at time of diagnosis and throughout the first year, in patients with suspected epithelial ovarian cancer (EOC). Methods Patients were recruited consecutively in the gynecological outpatient clinic at Aalborg University Hospital, Denmark from December 2014 to May 2017. All patients underwent a whole leg compression ultrasound scan (CUS), Computed Tomography (CT) of the thorax in arterial phase at time of inclusion, to be able to diagnose deep vein thrombosis (DVT) and pulmonary embolism (PE), respectively. Patients were followed and systematically screened for VTE throughout 12 months. Results Ninety-seven patients with suspected EOC were enrolled in the study and followed up. Within the group of EOC patients (N = 53) eleven were diagnosed with VTE during the first year from EOC diagnosis, the incidence of VTE at time of diagnosis was low (2/53–3.8%). No patients with borderline or benign ovarian neoplasms were diagnosed with VTE. One EOC patient had a VTE during the postoperative period and further eight EOC patients were diagnosed with VTE within the first year, during periods undergoing non-surgical cancer treatment. Median time to VTE was 87 days. Conclusions The one year cumulative incidence of VTE in EOC patients was 20.8% with a low incidence at time of diagnosis. A substantial number of VTE cases (73%) appeared during periods of non-surgical oncologic treatment. Future research should focus on risk factors and timing of VTE in EOC patients, as this could have important implications for future prophylaxis guidelines. |
Databáze: | OpenAIRE |
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