[Study on uric acid metabolism in patients with primary aldosteronism]
| Autor: | Tohru Ohtomo, Kenjiro Kikuchi, Hiroaki Komura, Shinichiro Suzuki, Masaaki Namba, Naotoshi Satoh, Shigeru Marusaki, Osamu Iimura, Tamaki Takada |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adenoma
Adult Male medicine.medical_specialty medicine.medical_treatment Sodium Adrenal Gland Neoplasms chemistry.chemical_element Kidney Tubules Proximal chemistry.chemical_compound Primary aldosteronism Internal medicine Hyperaldosteronism medicine Humans Aldosterone Renal sodium reabsorption Reabsorption Adrenalectomy Middle Aged medicine.disease Uric Acid Endocrinology chemistry Renal physiology Hypertension Uric acid Female |
| Zdroj: | Nihon Naibunpi Gakkai zasshi. 68(1) |
| ISSN: | 0029-0661 |
| Popis: | This study was conducted to elucidate renal uric acid metabolism in patients with primary aldosteronism (PA;16 cases) as compared with normotensive subjects (NT;25 cases) and essential hypertensives (EHT;51 cases). All subjects were hospitalized and received a regular diet(Na;120 mEq,K;75 mEq,daily) for more than two weeks, after which renal clearance tests were performed, and serum uric acid(SUA), fractional excretions of uric acid(FEUA), sodium(FENa), and inorganic phosphorus(FEP) were evaluated. Plasma aldosterone concentration(PAC) was measured in 16 patients with PA before treatment and in 8 patients after adrenalectomy. SUA was lower in PA than in either NT or EHT, and this lowering was more obvious in male subjects. In NT, PA and EHT, FEUA, an index of renal excretion of uric acid, correlated negatively with SUA and positively with FENa and FEP, which reflected sodium reabsorption at the renal total tubules and proximal tubules, respectively. Although FENa was nearly the same in all the three groups, FEUA and FEP were significantly higher in PA than in EHT or NT. However, no significant correlation was found between PAC and SUA or FEUA in PA. In PA a significant increase of SUA, and decreases of FEUA and FEP were observed after the removal of adenoma compared to before the surgery. These results suggest that uric acid transport might be closely related to sodium transport in the renal tubules, particularly at the proximal site, and also lead to the conclusion that the lower SUA in PA resulted from the suppression of reabsorption and/or an enhancement of secretion of uric acid in the proximal tubules, being related to the so-called escape phenomenon. |
| Databáze: | OpenAIRE |
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