Ultrastructural changes in mouse Leydig cells after streptozotocin administration
| Autor: | Yoshihiro Hayashi, Kenji Ogawa, Masamichi Kurohmaru, Roberto E. Sanguinetti |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Biology Endoplasmic Reticulum General Biochemistry Genetics and Molecular Biology Streptozocin Diabetes Mellitus Experimental Islets of Langerhans Mice Atrophy Internal medicine Lipid droplet Testis medicine Animals geography Mice Inbred ICR geography.geographical_feature_category General Veterinary Leydig cell Endoplasmic reticulum Leydig Cells Lipid metabolism General Medicine Islet Streptozotocin medicine.disease Lipid Metabolism Microscopy Electron medicine.anatomical_structure Endocrinology Animal Science and Zoology Pancreas medicine.drug |
| Zdroj: | Experimental animals. 44(1) |
| ISSN: | 1341-1357 |
| Popis: | Male ICR mice were intraperitoneally injected with a single dose (100 mg/kg BW) of streptozotocin (STZ). The pancreas and testis were excised at 1, 2 or 4 weeks after STZ administration and observed by light and electron microscopy. At 2 weeks after injection (p.i.), the islets of Langerhans in the pancreas showed severe atrophy, indicating a diabetic state. In the testis, although no conspicuous morphological changes were detected at 2 weeks p.i., noticeable changes had occurred in the Leydig cells at 4 weeks p.i. In the cells, lipid droplets increased in number, whereas smooth endoplasmic reticulum (sER) decreased. Giant whorl-like sER appeared frequently at this time. These findings indicate the declined secretory activity of Leydig cells in STZ diabetic mice. |
| Databáze: | OpenAIRE |
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