Association of elevated C-reactive protein levels with an impaired prognosis in patients with surgically treated endometrial cancer
| Autor: | Lukas Hefler, Alois Schneitter, Stefan Hinterberger, Maximilian Schmid, Alexander Reinthaller, Julia Seeber |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Pathology Kaplan-Meier Estimate Gastroenterology Disease-Free Survival Cohort Studies Internal medicine medicine Humans Lymph node Survival analysis Aged Neoplasm Staging Retrospective Studies biology business.industry Proportional hazards model Endometrial cancer C-reactive protein Acute-phase protein Obstetrics and Gynecology Cancer Retrospective cohort study Middle Aged medicine.disease Prognosis Endometrial Neoplasms medicine.anatomical_structure C-Reactive Protein biology.protein Female business Biomarkers |
| Zdroj: | Obstetrics and gynecology. 110(6) |
| ISSN: | 0029-7844 |
| Popis: | To evaluate whether C-reactive protein (CRP) serum levels are associated with prognosis in surgically treated endometrial cancer.In the present multicenter study, CRP serum levels were measured preoperatively in 403 surgically staged patients with endometrioid endometrial cancer. Results were correlated to clinical data.The mean (standard deviation) serum CRP level in patients with endometrial cancer was 1.0 (1.8) mg/dL. Serum CRP levels were associated with tumor stage (P=.01), but not with tumor grade (P=.8), lymph node involvement (P=.8), and age at diagnosis (P=.9). In a univariable survival analysis, serum CRP levels, tumor stage, tumor grade, and age at diagnosis were associated with disease-free and overall survival (all P.001). In a multivariable Cox regression model, serum CRP levels (P=.001, P=.004), tumor stage (P.001, P.001), tumor grade (P=.02, P=.009), and age at diagnosis (P=.002, P=.001) were independent prognostic factors for disease-free and overall survival.Our results suggest that elevated serum CRP levels are associated with a less favorable prognosis in patients with surgically treated endometrial cancer.II. |
| Databáze: | OpenAIRE |
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