Understanding Brain Reorganization in Infants With Perinatal Stroke Through Neuroexcitability and Neuroimaging
| Autor: | Kyle Rudser, Raghu Rao, Bryon A. Mueller, Mo Chen, Chao-Ying Chen, Jed T. Elison, Bernadette T. Gillick, Michael K. Georgieff, James W. Stinear |
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| Rok vydání: | 2017 |
| Předmět: |
Male
General movements assessment medicine.medical_specialty medicine.medical_treatment Pyramidal Tracts Physical Therapy Sports Therapy and Rehabilitation Motor Activity Article Cerebral palsy 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Neuroimaging 030225 pediatrics Neuroplasticity medicine Humans Stroke medicine.diagnostic_test business.industry Brain Infant Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Transcranial Magnetic Stimulation Transcranial magnetic stimulation Cross-Sectional Studies Pediatrics Perinatology and Child Health Corticospinal tract Female business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Pediatric Physical Therapy. 29:173-178 |
| ISSN: | 0898-5669 |
| DOI: | 10.1097/pep.0000000000000365 |
| Popis: | Purpose The primary aim of this proposed study is to evaluate brain reorganization patterns in infants with perinatal stroke between 3 and 5 months of age using transcranial magnetic stimulation and magnetic resonance imaging, with the addition of the General Movements Assessment. A secondary aim is to demonstrate feasibility and safety of infant-appropriate brain assessment protocols. Methods Ten infants with perinatal stroke will be enrolled. In this exploratory study, infants will first receive magnetic resonance imaging scanning during natural sleep to examine their corticospinal tract integrity. Infants will then receive transcranial magnetic stimulation to assess their corticomotor excitability. A General Movements Assessment video of at least 5 minutes will also be recorded. Discussion Study results will enhance our understanding of brain reorganization in infants with perinatal stroke. We expect these results will also guide the development of early interventions designed to mitigate maladaptive neuroplastic changes and improve long-term motor outcomes. |
| Databáze: | OpenAIRE |
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