New cytotoxic sesquiterpenes from the red algae Laurencia obtusa and Laurencia microcladia

Autor:	Constantinos Vagias, Maria Kladi, Helen Xenaki, Vassilios Roussis, Panagiota Papazafiri
Rok vydání:	2006
Předmět:	biology Stereochemistry Organic Chemistry Laurencia General Medicine Red algae Laurencia obtusa biology.organism_classification Sesquiterpene Biochemistry Terpene Human tumor chemistry.chemical_compound chemistry Botany Drug Discovery Spectral data Microcladia
Zdroj:	Tetrahedron. 62:182-189
ISSN:	0040-4020
DOI:	10.1016/j.tet.2005.09.113
Popis:	Three new sesquiterpenes ( 1–3 ), along with five known ( 5–9 ), were isolated from the organic extract of the red alga Laurencia obtusa, collected from the coastal rocks of Serifos in the Aegean Sea. A new dimeric sesquiterpene of the cyclolaurane-type ( 4 ) along with four previously reported ( 7 , 10–12 ) metabolites, were isolated from the extract of Laurencia microcladia, collected at Chios island in the North Aegean Sea. The structures and the relative stereochemistry of the compounds are proposed on the basis of their spectral data. The cytotoxicity of the isolated metabolites was evaluated against several cell lines including human tumor cell lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f416f07f1ba8b8ff325e547ee397356 https://doi.org/10.1016/j.tet.2005.09.113 Zobrazit plný text záznamu Full Text from ScienceDirect