Liver Transplantation from Female Donors Provokes Higher Complement Component C5a Activity
Autor: | Ineko Kato, Fujio Hara, Masahito Hibi, Kabe Kazuhiko, Takazumi Kato, Hajime Togari, Masanori Tamura, Tetsuya Ito, Ghada A. Daoud, Hirokazu Tomishige, Tatsuya Suzuki, Mohamed Hamed Hussein, Takashi Hashimoto, Hisanori Sobajima |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Male
Adolescent Base Pair Mismatch medicine.medical_treatment Physiology Complement C5a Liver transplantation medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Postoperative Complications Sex Factors 030202 anesthesiology Lactate dehydrogenase Living related liver transplantation medicine Humans Child Transplantation Original Paper business.industry Incidence (epidemiology) Incidence Infant Glutamic-Oxaloacetic Transaminase General Medicine Hydrogen Peroxide Serum samples Prognosis Tissue Donors Liver Transplantation Oxidative Stress Outpatient visits chemistry Child Preschool Immunology Female business 030217 neurology & neurosurgery Oxidative stress |
Zdroj: | Annals of Transplantation |
ISSN: | 2329-0358 1425-9524 |
Popis: | Background Transplanted organs from female donors are associated with less favorable prognoses and outcomes. This study aimed to determine whether donor gender affects levels of serum terminal complement component C5a and oxidative stress in pediatric living related liver transplantation (LRLTx) recipients. Material/Methods The subjects were 43 patients (20 males and 23 females) who underwent LRLTx during childhood (age range 1.2 years to 14.4 years; mean age 5 years). Serum samples were taken during the patients’ regular outpatient visits after LRLTx. Serum C5a was measured using the specific human C5a ELISA kit. Serum total hydroperoxide (TH) and biological antioxidative potential (BAP) were measured using the free radical analytic system, and the oxidative stress index (OSI) was calculated as the ratio of TH to BAP. Serum glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT), gamma-glutamyl transpeptidase (γGTP), and lactate dehydrogenase (LDH) were also measured as part of a typical outpatient examination for such patients. Results C5a serum levels were higher in the 29 recipients who received their grafted livers from female donors than in the 14 recipients who received their grafted livers from male donors. Recipients who received their grafted livers from female donors had higher incidence of post-LTx (liver transplantation) complications. Female recipients from female donors showed the highest serum GPT and GOT levels, but this difference was only significant when compared to the female recipients from male donors (41.4±9.8 IU/L vs. 17.3±1.8 IU/L for GPT and 42.2±7.5 IU/L vs. 23.4±2.2 IU/L for GOT; P Conclusions Pediatric LRLTx patients who receive their grafts from female donors exhibit higher levels of serum C5a that probably plays a role in the immunological response against grafted livers from female donors in LTx. |
Databáze: | OpenAIRE |
Externí odkaz: |