TSH CROSSLINKS TO THE TSH RECEPTOR THROUGH THE β SUBUNIT
| Autor: | Paul Robert Buckland, Thomas W. Strickland, Bernard Rees Smith, John G. Pierce |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Azides
endocrine system medicine.medical_specialty endocrine system diseases Swine Protein subunit Thyrotropin Adenylate kinase Receptors Cell Surface macromolecular substances Cyclase Thyrotropin receptor Endocrinology Internal medicine β subunit medicine Animals Receptor Antiserum Chemistry technology industry and agriculture Receptors Thyrotropin Cross-Linking Reagents Thyroid Follicular Cells Autoradiography hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrinology. 116:2122-2124 |
| ISSN: | 1945-7170 0013-7227 |
| Popis: | TSH binds specifically to the TSH receptor present on the surface of thyroid follicular cells and consequently activates adenylate cyclase. It was not known, however, which of the two subunits of the TSH bound to the receptor. By covalently crosslinking TSH to its receptor and characterizing the product with antisera specific for either the alpha or beta subunit of TSH, we have shown that the TSH beta subunit but not the TSH alpha subunit crosslinks to the TSH receptor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|