Persistent Lipophilic Environmental Chemicals and Endometriosis: The ENDO Study

Autor:	Rajeshwari Sundaram, Ann Trumble, Kurunthachalam Kannan, Zhen Chen, Linda C. Giudice, Michael W. Varner, Mary L. Hediger, Joseph B. Stanford, C. Matthew Peterson, Mary S. Croughan, Germaine M. Buck Louis, Victor Y. Fujimoto, Patrick J. Parsons
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	Adult medicine.medical_specialty polybrominated diphenyl ethers genetic structures polychlorinated biphenyls Health Toxicology and Mutagenesis Endometriosis Physiology California Gas Chromatography-Mass Spectrometry Cohort Studies chemistry.chemical_compound organochlorine pesticides Internal medicine Utah Organochlorine pollutants medicine Hydrocarbons Chlorinated Odds Ratio Humans endocrine-disrupting chemicals Research Public Health Environmental and Occupational Health Organochlorine pesticide medicine.disease Magnetic Resonance Imaging Hydrocarbons.chlorinated Endocrinology Logistic Models chemistry persistent organochlorine pollutants Environmental Pollutants Female Laparoscopy Lindane Omentum Hexachlorocyclohexane
Zdroj:	Environmental Health Perspectives
ISSN:	1552-9924 0091-6765
Popis:	Background: An equivocal literature exists regarding the relation between persistent organochlorine pollutants (POPs) and endometriosis in women, with differences attributed to methodologies. Objectives: We assessed the association between POPs and the odds of an endometriosis diagnosis and the consistency of findings by biological medium and study cohort. Methods: Using a matched cohort design, we assembled an operative cohort of women 18–44 years of age undergoing laparoscopy or laparotomy at 14 participating clinical centers from 2007 to 2009 and a population-based cohort matched on age and residence within a 50-mile catchment area of the clinical centers. Endometriosis was defined as visualized disease in the operative cohort and as diagnosed by magnetic resonance imaging in the population cohort. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for each POP in relation to an endometriosis diagnosis, with separate models run for each medium (omental fat in the operative cohort, serum in both cohorts) and cohort. Adjusted models included age, body mass index, breast-feeding conditional on parity, cotinine, and lipids. Results: Concentrations were higher in omental fat than in serum for all POPs. In the operative cohort, γ-hexachlorocyclohexane (γ-HCH) was the only POP with a significant positive association with endometriosis [per 1-SD increase in log-transformed γ-HCH: adjusted OR (AOR) = 1.27; 95% CI: 1.01, 1.59]; β-HCH was the only significant predictor in the population cohort (per 1-SD increase in log-transformed β-HCH: AOR = 1.72; 95% CI: 1.09, 2.72). Conclusions: Using a matched cohort design, we found that cohort-specific and biological-medium–specific POPs were associated with endometriosis, underscoring the importance of methodological considerations when interpreting findings.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3dc9a89db1548a406b207eb622ad83 http://europepmc.org/articles/PMC3385438 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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