Risk Factors for Failure of Initial Intravenous Immunoglobulin Treatment in Kawasaki Disease
| Autor: | Kyung Lim Yoon, Yong-Joo Ahn, Sungho Cha, Minjeong Yoon, Mi-Young Han |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Bilirubin Mucocutaneous Lymph Node Syndrome Gastroenterology Group A Group B chemistry.chemical_compound Risk Factors Internal medicine hemic and lymphatic diseases medicine Humans Treatment Failure Prospective cohort study biology business.industry C-reactive protein Coronary Aneurysm Immunoglobulins Intravenous Infant General Medicine medicine.disease Surgery C-Reactive Protein chemistry Child Preschool biology.protein Abnormal Liver Function Test Kawasaki disease Original Article Female Antibody business |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| Popis: | The aims of this study were to determine the occurrence and variables associated with the initial intravenous immunoglobulin (IVIG) treatment failure in Kawasaki disease (KD) and to categorize differences in clinical characteristics between responders and nonresponders to initial IVIG treatment. Patients were classified into two groups. Group A included 33 patients who received a single dose of IVIG treatment and responded. Group B included 18 patients who received more than two doses of IVIG due to failure of the initial treatment. The mean duration of fever after initial treatment in group B was significantly longer than it was in group A. In group B, we found that higher bilirubin, aspartate aminotransferase (AST), polymorphonuclear cells (PMN) (%), and lower platelet values at baseline were independent predictors of persistent or recurrent fever in patients with KD. Coronary artery abnormalities were found in 8 patients (44.4%) in group B and in two patients (6.1%) in group A. We found that abnormal liver function tests and a lower platelet count at baseline were possible predictors of nonresponders to IVIG in patients with KD. There is a need for a prospective study focused on baseline hepatobiliary parameters. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|