Reduction of 0.1 Hz microcirculatory fluctuations as evidence of sympathetic dysfunction in insulin-dependent diabetes
| Autor: | Gabriele Fornasari, A. Calciati, Cesare Orlandi, Marco Rossi, Luciano Bernardi, Stefano Leuzzi, Emilio Mevio, Pietro Fratino |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Sympathetic nervous system Sympathetic Nervous System Physiology Diaphragmatic breathing Vasomotion Microcirculation Forearm Physiology (medical) Internal medicine Diabetes mellitus medicine Laser-Doppler Flowmetry Heart rate variability Humans Skin business.industry Signal Processing Computer-Assisted Middle Aged medicine.disease Autonomic nervous system medicine.anatomical_structure Endocrinology Diabetes Mellitus Type 1 Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiovascular research. 34(1) |
| ISSN: | 0008-6363 |
| Popis: | Objective: Loss of spontaneous fluctuations in resting microcirculatory flow has been described in diabetes mellitus, but its mechanism remains unexplained. Methods: The autonomic control of forearm skin microcirculation was investigated in 23 insulin-dependent diabetic human subjects (median age 39 years, range 27–50) and in 23 age-matched controls (median age 38 years, range 20–57), by laser-Doppler flowmetry. Using spectral analysis of spontaneous microvascular fluctuations, we measured the power of 0.1 Hz (‘10-second rhythm’) fluctuations, dependent on sympathetic control, and of respiration-related, high-frequency fluctuations, due to the transmission of mechanical chest activity. Autonomic function abnormalities were assessed by 5 tests of cardiovascular reflexes. Results: Abnormalities in cardiovascular autonomic tests were present in 7/23 patients: deep breathing was abnormal 4 in patients, standing in 2, handgrip in 3, cross-correlation in 4, and Valsalva ratio in 0. The power of 0.1 Hz microcirculatory fluctuations was significantly lower in diabetic than in control subjects (2.57±0.16 vs 3.48±0.09 ln-mV2, mean±s.e.m., P |
| Databáze: | OpenAIRE |
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