Ratio of Klebsiella/Bifidobacterium in early life correlates with later development of paediatric allergy
| Autor: | Joanna D. Holbrook, Oon-Hoe Teoh, J.S.Y. Low, Y.K. Lee, Shu E Soh, Keith M. Godfrey, Jan Knol, Anne Eng Neo Goh, Yap Seng Chong, Lynette Pei-Chi Shek, E.M. van der Beek, Christophe Lay, Kenneth Kwek |
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| Přispěvatelé: | Center for Liver, Digestive and Metabolic Diseases (CLDM), Reproductive Origins of Adult Health and Disease (ROAHD) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Allergy ved/biology.organism_classification_rank.species Eczema CHILDHOOD INFANTS Disease Gut flora CLOSTRIDIUM-DIFFICILE Microbiologie Klebsiella RNA Ribosomal 16S Cluster Analysis ATOPIC-DERMATITIS Phylogeny Bifidobacterium RISK Singapore Bifidobacterium breve biology atopic dermatitis GUT MICROBIOTA Atopic dermatitis Biota Child Preschool Biomarker (medicine) Female eczema DNA Bacterial Microbiology (medical) DNA Ribosomal Microbiology Article 03 medical and health sciences Enterobacteriaceae INTESTINAL MICROBIOTA BIFIDOBACTERIUM-BREVE Hypersensitivity medicine Humans 16S rRNA FECAL MICROFLORA VLAG ved/biology Infant Newborn 1ST YEAR Infant Sequence Analysis DNA Odds ratio medicine.disease biology.organism_classification Bacterial Load 030104 developmental biology Case-Control Studies Immunology Bifidobacterium spp Dysbiosis Follow-Up Studies |
| Zdroj: | Beneficial microbes, 8(5), 681-695. Wageningen Academic Publishers Beneficial Microbes, 8(5), 681-695 Beneficial Microbes 8 (2017) 5 |
| ISSN: | 1876-2883 |
| DOI: | 10.3920/bm2017.0020 |
| Popis: | Several studies have reported that intestinal microbial colonization patterns differ between non-allergic and allergic infants. However, the microbial signature underlying the pathogenesis of allergies remains unclear. We aim to gain insight into the development of the intestinal microbiota of healthy infants and infants who develop allergy in early life, and identify potential microbiota biomarkers of later allergic disease. Using a case-control design in a Chinese sub-cohort of a Singaporean birth cohort (GUSTO), we utilized 16S rRNA gene sequencing to assess intestinal microbial composition and diversity of 21 allergic and 18 healthy infants at 3 weeks, 3 months and 6 months of age, and correlated the microbiota with allergy at ages 18 and 36 months. Pronounced differences in intestinal microbiota composition between allergic and healthy infants were observed at 3 months of age. The intestine of healthy infants was colonised with higher abundance of commensal Bifidobacterium. Conversely, Klebsiella, an opportunistic pathogen, was significantly enriched in the allergic infants. Interestingly, infants with a high Klebsiella/Bifidobacterium (K/B) ratio (above the population median K/B ratio) at age 3 months had an odds ratio of developing allergy by 3 years of age of 9.00 (95% confidence interval 1.46 – 55.50) compared to those with low K/B ratio. This study demonstrated a relationship between the ratio of genera Klebsiella and Bifidobacterium during early infancy and development of paediatric allergy in childhood. Our study postulates that an elevated Klebsiella/Bifidobacterium ratio in early infancy could be a potential indicator of an increased risk of allergy development. This line of research might enable future intervention strategies in early life to prevent or treat allergy. Our study provides new insights into microbial signatures associated with childhood allergy, in particular, suggests that an elevated Klebsiella/Bifidobacterium ratio could be a potential early-life microbiota biomarker of allergic disease. |
| Databáze: | OpenAIRE |
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