Altered monetary loss processing and reinforcement-based learning in individuals with obesity
| Autor: | Sonja A. Kotz, David Mathar, Annette Horstmann, Arno Villringer, Jana Kube, Jane Neumann |
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| Přispěvatelé: | RS: FPN NPPP I, Section Neuropsychology |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
NEURAL BASIS Prediction error DECISION-MAKING Choice Behavior CONFIDENCE-INTERVALS Behavioral Neuroscience 0302 clinical medicine Neural Pathways SEEKING BEHAVIOR Reinforcement Prefrontal cortex Original Research Brain Mapping medicine.diagnostic_test 05 social sciences Neuropsychology Brain Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure Neurology Female Psychology STRIATAL RESPONSE Reinforcement Psychology Cognitive psychology Adult Cognitive Neuroscience NUCLEUS-ACCUMBENS Dysfunctional family Models Psychological 03 medical and health sciences Cellular and Molecular Neuroscience POSITRON-EMISSION-TOMOGRAPHY WORKING-MEMORY Reward Fmri medicine Journal Article Humans Computer Simulation 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging 050102 behavioral science & comparative psychology Obesity Working memory Ventral striatum Money REWARD PREDICTION ERRORS ANTERIOR INSULA Neurology (clinical) Probability Learning Functional magnetic resonance imaging Insula 030217 neurology & neurosurgery |
| Zdroj: | Brain Imaging and Behavior, 12(5). Springer, Cham Brain Imaging and Behavior |
| ISSN: | 1931-7557 |
| Popis: | Individuals with obesity are often characterized by alterations in reward processing. This may affect how new information is used to update stimulus values during reinforcement-based learning. Here, we investigated obesity-related changes in non-food reinforcement processing, their impact on learning performance as well as the neural underpinnings of reinforcement-based learning in obesity. Nineteen individuals with obesity (BMI > = 30 kg/m2, 10 female) and 23 lean control participants (BMI 18.5–24.9 kg/m2, 11 female) performed a probabilistic learning task during functional magnetic resonance imaging (fMRI), in which they learned to choose between advantageous and disadvantageous choice options in separate monetary gain, loss, and neutral conditions. During learning individuals with obesity made a significantly lower number of correct choices and accumulated a significantly lower overall monetary outcome than lean control participants. FMRI analyses revealed aberrant medial prefrontal cortex responses to monetary losses in individuals with obesity. There were no significant group differences in the regional representation of prediction errors. However, we found evidence for increased functional connectivity between the ventral striatum and insula in individuals with obesity. The present results suggest that obesity is associated with aberrant value representations for monetary losses, alterations in functional connectivity during the processing of learning outcomes, as well as a decresased reinforcement-based learning performance. This may affect how new information is incorporated to adjust dysfunctional behavior and could be a factor contributing to the maintenance of dysfunctional eating behavior in obesity. Electronic supplementary material The online version of this article (10.1007/s11682-017-9786-8) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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