Associations of Diet Quality with Midlife Brain Volume: Findings from the UK Biobank Cohort Study
| Autor: | Catherine M. Milte, Helen Macpherson, Karen E. Lamb, Sarah A. McNaughton |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Aging Mediterranean diet Grey matter Diet Mediterranean Hippocampus Cohort Studies White matter Surveys and Questionnaires Image Processing Computer-Assisted medicine Humans Dementia Gray Matter business.industry General Neuroscience Confounding Brain General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging White Matter Biobank United Kingdom Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Brain size Female Diet Healthy Geriatrics and Gerontology business Cohort study Demography |
| Zdroj: | Journal of Alzheimer's Disease. 84:79-90 |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background: Higher quality diets may be related to lower dementia rates. Midlife is emerging as a critical life stage for a number of dementia risk factors. Objective: This study examines whether diet quality is related to brain structure during midlife, and if this differs by sex. Methods: This study used data from 19184 UK Biobank participants aged 40–65 years. Diet quality was assessed using three dietary indices including the Mediterranean Diet Score (MDS), Healthy Diet Score (HDS), and Recommended Food Score (RFS). MRI brain measures included total, grey, white and hippocampal volume. Linear regression examined associations between diet quality and brain volume, controlling for potential confounders. Results: Better quality diet across all indices was significantly related to larger grey matter volume: MDS β= 429.7 (95%CI: 65.2, 794.2); HDS β= 700.1 (348.0, 1052.1); and RFS β= 317.1 (106.8, 527.3). Higher diet scores were associated with greater total volume: HDS β= 879.32 (286.13, 1472.50); RFS β= 563.37 (209.10, 917.65); and white matter volume: RFS β= 246.31 (20.56, 472.05), with the exception of Mediterranean diet adherence. Healthy eating guidelines and dietary variety associations with total and grey matter volume were more prominent in men. Conclusion: Findings suggest that diet quality is associated with brain structure during midlife, potentially decades prior to the onset of dementia. |
| Databáze: | OpenAIRE |
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