Screening of Nutraceuticals and Plant Extracts for Inhibition of Amyloid-β Fibrillation
| Autor: | Ago Samoson, Raiker Witter, Steffi Witter, Raivo Vilu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Amyloid Amyloid β Pharmacology law.invention Centella 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Nutraceutical Alzheimer Disease law medicine Humans Pathogen Fibrillation Amyloid beta-Peptides Methionine Plant Extracts General Neuroscience Aβ peptide General Medicine Peptide Fragments Triterpenes In vitro Psychiatry and Mental health Clinical Psychology Spectrometry Fluorescence 030104 developmental biology chemistry Dietary Supplements Geriatrics and Gerontology medicine.symptom Phytotherapy 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 73:1003-1012 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-190758 |
| Popis: | Fluorescence spectroscopy for in vitro amyloid-β (Aβ) fibrillation diagnosis and spectral fluorescence signature for the identification of bioactive compounds were applied to study traditional Ayurvedic nutraceuticals - Brahmi, Ashwagandha, Shanka pushpi, and Gotu kola - as well as their plant extracts for possible treatment of Alzheimer's disease. All samples manifest as inhibitors on three different variants of the Aβ peptide: methionine Aβ1-40, Aβ1-40, and Aβ1-42. The main compounds within the nutraceuticals were identified. Since related medicals are known to have reduced negative post- and side-effects and even may introduce further positive health impacts by preventing pathogen plaque formation and reducing free Aβ to a natural level, such treatment approaches could be of further interest. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|