Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder
| Autor: | Mariella Raffo, Michelle Hampson, Cheryl Lacadie, Pawel Skudlarski, Hilary P. Blumberg, Fei Wang, Brian Pittman, Lara G. Chepenik, Monique M. Jones |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Bipolar Disorder Adolescent Rest Neuroscience (miscellaneous) Prefrontal Cortex Brain mapping Amygdala Article Young Adult Neural Pathways Image Processing Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Bipolar disorder Prefrontal cortex Brain Mapping Resting state fMRI Functional connectivity Ventral striatum Middle Aged medicine.disease Magnetic Resonance Imaging Oxygen Resting state functional magnetic resonance imaging Psychiatry and Mental health medicine.anatomical_structure nervous system Female Psychology Neuroscience psychological phenomena and processes |
| Zdroj: | Psychiatry Research: Neuroimaging. 182:207-210 |
| ISSN: | 0925-4927 |
| Popis: | Trait abnormalities in bipolar disorder (BD) within ventral prefrontal cortex (vPFC) and amygdala suggest dysfunction in their connectivity. This study employed low frequency resting state functional magnetic resonance imaging (LFRS-fMRI) to analyze functional connectivity between ventral prefrontal cortex (vPFC) and amygdala in BD. LFRS-fMRI identified a negative correlation in vPFC-amygdala activity, and the magnitude of this correlation was greater in healthy participants than in subjects with BD. Additionally, whole brain analysis revealed higher correlations between left and right vPFC in BD, as well as with ventral striatum. |
| Databáze: | OpenAIRE |
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