Kinetic Resolution of Tertiary Alcohols by Chiral Organotin-Catalyzed O-Acylation

Autor:	Jian Song, Wen-Hua Zheng
Rok vydání:	2022
Předmět:	Organic Chemistry Physical and Theoretical Chemistry Biochemistry
Zdroj:	Organic Letters. 24:2349-2353
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.2c00537
Popis:	A novel highly enantioselective method for the kinetic resolution of racemic tertiary alcohols has been achieved through chiral organotin-catalyzed intermolecular acylation of the hydroxyl group. This process has demonstrated a broad substrate scope (both alkyl- and aryl-substituted tertiary alcohols) with high enantioselectivity under mild reaction conditions, affording the corresponding products and the recovered tertiary alcohols with high enantioselectivities, with
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f37cf22bb837a8514194e2839bb3a27 https://doi.org/10.1021/acs.orglett.2c00537 Zobrazit plný text záznamu