EP2 and EP3 receptors as therapeutic targets for underactive bladder/detrusor underactivity due to diabetic cystopathy in a type 1 diabetic rat model
| Autor: | Jun Kida, Hiroko Mashimo, Daisuke Wakamatsu, Hidekazu Matsuya, Noritoshi Sekido, Takeya Otsuki, Hiroki Okada |
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| Rok vydání: | 2020 |
| Předmět: |
Agonist
Male Tamsulosin medicine.medical_specialty medicine.drug_class Urology 030232 urology & nephrology Stimulation Pyridinium Compounds Underactive bladder Diabetes Mellitus Experimental Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Urinary Bladder Underactive medicine Animals Diabetic Nephropathies Distigmine 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Cystometry Receptors Prostaglandin E EP2 Subtype medicine.disease Streptozotocin Thiazoles Diabetes Mellitus Type 1 Neurology Receptors Prostaglandin E EP3 Subtype Adrenergic alpha-1 Receptor Antagonists Urological Agents Cholinesterase Inhibitors business medicine.drug |
| Zdroj: | Lower urinary tract symptomsREFERENCES. 12(3) |
| ISSN: | 1757-5672 |
| Popis: | OBJECTIVES Diabetic cystopathy (DC) is recognized as one of the major etiologies of underactive bladder (UAB)/detrusor underactivity (DU). Although DC was first reported about three decades ago, there is a distinct lack of effective pharmacological management methods for UAB/DU due to DC with a robust certainty of evidence. In this study, we investigated whether EP2 and EP3 receptors are promising targets of pharmacological management of UAB/DU due to DC. METHODS We used streptozotocin (STZ)-induced diabetic Sprague-Dawley rats with postvoid residual urine (PVR) greater than 0.1 mL. Sixteen weeks after induction of diabetes, we performed awake single cystometry after oral administration of the vehicle, an α-blocker (tamsulosin [TAM], 0.1 and 0.3 mg/kg), a cholinesterase inhibitor (distigmine [DIS], 0.3 and 1.0 mg/kg), or an EP2/3 dual agonist (ONO-8055, 0.01 and 0.03 mg/kg). We compared cystometric parameters after administration of the vehicle and drugs using a paired t test. P |
| Databáze: | OpenAIRE |
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