Innate Lymphocyte/Ly6C hi Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance
| Autor: | James W. Keith, Dane Samilo, Eric G. Pamer, Ingrid Leiner, Rebecca A. Carter, Huizhong Xiong |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Lymphocyte Inflammation Biology Monocytes Article General Biochemistry Genetics and Molecular Biology Microbiology Mice 03 medical and health sciences 0302 clinical medicine medicine Animals Lymphocytes Lung Pathogen Innate immune system Tumor Necrosis Factor-alpha Monocyte Interleukin-17 Innate lymphoid cell Klebsiella Infections respiratory tract diseases Klebsiella pneumoniae 030104 developmental biology medicine.anatomical_structure Immunology Tumor necrosis factor alpha Interleukin 17 medicine.symptom 030215 immunology |
| Zdroj: | Cell. 165:679-689 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2016.03.017 |
| Popis: | Increasing antibiotic resistance among bacterial pathogens has rendered some infections untreatable with available antibiotics. Klebsiella pneumoniae, a bacterial pathogen that has acquired high-level antibiotic resistance, is a common cause of pulmonary infections. Optimal clearance of K. pneumoniae from the host lung requires TNF and IL-17A. Herein we demonstrate that inflammatory monocytes are rapidly recruited to the lungs of K. pneumoniae infected mice, and produce TNF, which markedly increases the frequency of IL-17-producing innate lymphoid cells. While pulmonary clearance of K. pneumoniae is preserved in neutrophil-depleted mice, monocyte depletion or TNF deficiency impairs IL-17A–dependent resolution of pneumonia. Monocyte-mediated bacterial uptake and killing is enhanced by ILC production of IL-17A, indicating that innate lymphocytes engage in a positive feedback loop with monocytes that promotes clearance of pneumonia. Innate immune defense against a highly antibiotic-resistant bacterial pathogen depends on crosstalk between inflammatory monocytes and innate lymphocytes that is mediated by TNF and IL-17A. |
| Databáze: | OpenAIRE |
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