Targeting TCTP with Sertraline and Thioridazine in Cancer Treatment
| Autor: | Robert Amson, Judith E. Karp, Christian Auclair, Adam Telerman, Fabrice Andre |
|---|---|
| Přispěvatelé: | Laboratoire de Biologie et de Pharmacologie Appliquée (LBPA), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Institut Gustave Roussy (IGR), Pathologie mammaire, Département de médecine oncologique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Biomarqueurs prédictifs et nouvelles stratégies moléculaires en thérapeutique anticancéreuse (U981), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Programmed cell death Sertraline [SDV.GEN]Life Sciences [q-bio]/Genetics business.industry [SDV]Life Sciences [q-bio] Columbia university Cancer [SDV.CAN]Life Sciences [q-bio]/Cancer Thioridazine [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences medicine.disease 3. Good health Cancer treatment Clinical study 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Cancer cell medicine Cancer research [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology business medicine.drug |
| Zdroj: | TCTP/tpt1-Remodeling Signaling from Stem Cell to Disease TCTP/tpt1-Remodeling Signaling from Stem Cell to Disease, 64, pp.283-290, 2017, ⟨10.1007/978-3-319-67591-6_15⟩ Results and Problems in Cell Differentiation ISBN: 9783319675909 |
| Popis: | International audience; We have initially demonstrated in knocking down experiments that decreasing TCTP in cancer cells leads in some tissues to cell death while in others to a complete reorganization of the tumor into architectural structures reminiscent of normal ones. Based on these experiments and a series of other findings confirming the key role of TCTP in cancer, it became important to find pharmacological compounds to inhibit its function, and this became for us a priority. In the present text, we explain in detail the experiments that were performed and the perspectives of sertraline in cancer treatment, as this became today a reality with a clinical study that started in collaboration with Columbia University and Johns Hopkins University. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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