Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study

Autor: Per Magne Ueland, Anne Tjønneland, Nicholas J. Wareham, Petra H.M. Peeters, Richard Palmqvist, Stein Emil Vollset, Marc J. Gunter, Kim Overvad, Miren Dorronsoro, Amanda J. Cross, Giovanna Masala, J. Ramón Quirós, Øivind Midttun, Krasimira Aleksandrova, Dimitrios Trichopoulos, Aurelio Barricarte, Yunxia Lu, Ruth C. Travis, Bas Bueno-de-Mesquita, Tilman Kuehn, Shu Chun Chuang, Claudia Agnoli, José María Huerta, Tobias Pischon, Martin Lajous, Heiner Boeing, Marie-Christine Boutron-Ruault, Pagona Lagiou, Antonia Trichopoulou, Guy Fagherazzi, Rosario Tumino, Rudolf Kaaks, Kay-Tee Khaw, Amalia Mattiello, Antonio Agudo, Esther Molina-Montes, Dagmar Drogan, Elisabete Weiderpass, Paolo Vineis, Elio Riboli, Ingrid Ljuslinder
Přispěvatelé: University Medical Center Utrecht, Imperial College Trust, [Chuang,S] Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan.[Chuang,S, Bueno-de-Mesquita,B, Peeter,PH, Gunter,M, Lu,Y, Cross,AJ, Riboli,E, Vineis,P] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. [Boeing,H] Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany. [Vollset,SE] Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway. Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway. [Midttun,O] Bevital AS, Bergen, Norway. [Ueland,PM] Department of Clinical Science, University of Bergen, Bergen, Norway. Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway. [Bueno-de-Mesquita,B] The National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands. Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. [Lajous,M, Fagherazzi,G, Boutron-Ruault,M] Inserm, Centre for research in Epidemiology and Population Health (CESP), Nutrition, Hormones and Women’s Health team, Villejuif, France. University of Paris Sud, Villejuif, France. IGR, Villejuif, France. [Kaaks,R, Küehn,T] Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany. [Pischon,T] Molecular Epidemiology Group, Max Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany. [Drogan,D] Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany. [Tjønneland,A] Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark. [Overvad,K] Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark. [Quirós,JR] Public Health Directorate, Asturias, Oviedo, Spain. [Agudo,A] Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology-ICO, IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain. [Molina-Montes,E] Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria de Granada (Granada.ibs), Granada, Spain. [Molina-Montes,E, Huerta,JM] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP), Madrid, Spain. [Dorronsoro,M] Epidemiology and Health Information, Public Health Division of Gipuzkoa, Basque Regional Health Department, San Sebastian, Spain. [Huerta,JM] Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain. [Barricarte,A] Navarre Public Health Institute, Pamplona, Spain. [Khaw,K] Clinical Gerontology Unit, Addenbrooke’s Hospital, University of Cambridge School of Clinical Medicine, Cambridge, UK. [Wareham,NJ] MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK. [Travis,RC, Trichopoulou,A] Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. [Trichopoulou,A, Trichopoulos,D] Hellenic Health Foundation, Athens, Greece. [Lagiou,P] Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece. Department of Epidemiology, Harvard School of Public Health, Boston, USA. [Lagiou,P, Trichopoulos,D] Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece. [Masala,G] Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy. [Agnoli,C] Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. [Tumino,R] Cancer Registry and Histopathology Unit, 'Civic - M.P. Arezzo' Hospital, ASP Ragusa, Italy. [Mattiello,A] Dipartamento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy. [Peeters,PH] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. [Weiderpass,E] Department of Community Medicine, Faculty of Health Sciences, University of Tromso, Tromsø, Norway. Department of Research, Cancer Registry of Norway, Oslo, Norway. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Samfundet Folkhälsan, Helsinki, Finland. [Palmqvist,R] Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden. [Ljuslinder,I] Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden. [Aleksandrova,K] Nutrition, Immunity and Metabolism Start-up Lab, Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., The EPIC cohort is supported by the Europe Against Cancer Program of the European Commission (SANCO). The individual centers also received funding from: Denmark: Danish Cancer Society, France: Ligue centre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM), Greece: the Hellenic Health Foundation, the Stavros Niarchos Foundation, and the Hellenic Ministry of Health and Social Solidarity, Germany : German Cancer Aid, and Federal Ministry of Education and Research, Italy: Italian Association for Research on Cancer and the National Research Council, The Netherlands: Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands, Norway: Helga – Nordforsk centre of excellence in food, nutrition and health and The Norwegian Extra Foundation for Health and Rehabilitation, The Norwegian Cancer Society, Spain: Health Research Fund (FIS) of the Spanish Ministry of Health (Exp 96/0032, RETICC DR06/ 0020), the Spanish Regional Governments of Andalusia, Asturias, Basque Country, Murcia (N0 6236), and the Navarra and the Catalan Institute of Oncology, Sweden: Swedish Cancer Society, Swedish Scientific Council, and Regional Governments of Skane and Västerbotten, UK: Cancer Research UK and Medical Research Council. Grant supports for the biochemical measurements: HDL-C and TG were analysed with additional support from the Ministry of Public Health, Welfare and Sports, the Netherlands,German Cancer Aid, Federal Ministry for Education and Research, European Union, European Union and AIRC-ITALY , German Cancer Aid, Federal Ministry for Education and Research, European Union, Stavros Niarchos Foundation , Hellenic Ministry of Health, Hellenic Health Foundation, MRC and Cancer Research UK, Hba1c was analysed with additional support from National Cancer Institute grant 1RO1CA102460 and data analyses on CRP were performed with support from World Cancer Research Fund International and Wereld Kanker Onderzoek Fonds (WCRF NL)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Aging
Síndrome metabòlica
Geriatrics & Gerontology
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research Design [Medical Subject Headings]
030204 cardiovascular system & hematology
Cardiovascular
Gastroenterology
chemistry.chemical_compound
0302 clinical medicine
immune system diseases
GENETIC-VARIANTS
Hyperlipidemia
HORDALAND HEALTH
Metabolic syndrome
Cell-mediated immunity
Neopterin
Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes [Medical Subject Headings]
3. Good health
European Prospective Investigation into Cancer and Nutrition
PROGNOSTIC VALUE
Neopterina
Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Lipid Metabolism Disorders::Dyslipidemias::Hyperlipidemias [Medical Subject Headings]
1107 Immunology
Biomarker (medicine)
CORONARY-ARTERY-DISEASE
Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds
2-Ring::Pteridines::Pterins::Biopterin::Neopterin [Medical Subject Headings]
Life Sciences & Biomedicine
SERUM NEOPTERIN
medicine.medical_specialty
Clinical Sciences
Immunology
Clinical nutrition
Procesos Bioquímicos
ADVERSE CARDIAC EVENTS
03 medical and health sciences
Clinical Research
Internal medicine
medicine
Journal Article
Nutrition
COLORECTAL-CANCER RISK
Cancer och onkologi
Proyectos de Investigación
Science & Technology
INTERFERON-GAMMA
business.industry
Research
1103 Clinical Sciences
medicine.disease
Ageing
030104 developmental biology
Blood pressure
Endocrinology
SYSTEM ACTIVATION
chemistry
Cardiovascular and Metabolic Diseases
Cancer and Oncology
Glycated hemoglobin
Hiperlipidemias
business
Hiperlipèmia
Zdroj: Immunity and Ageing, 13. BioMed Central
Immunity & ageing : I & A, vol 13, iss 1
Chuang, S-C; Boeing, H; Vollset, SE; Midttun, Ø; Ueland, PM; Bueno-de-Mesquita, B; et al.(2016). Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study.. Immunity & ageing : I & A, 13, 5. doi: 10.1186/s12979-016-0059-y. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/99g8x86j
Immunity & Ageing : I & A
Chuang, S-C, Boeing, H, Vollset, S E, Midttun, Ø, Ueland, P M, Bueno-de-Mesquita, B, Lajous, M, Fagherazzi, G, Boutron-Ruault, M-C, Kaaks, R, Küehn, T, Pischon, T, Drogan, D, Tjønneland, A, Overvad, K, Quirós, J R, Agudo, A, Molina-Montes, E, Dorronsoro, M, Huerta, J M, Barricarte, A, Khaw, K-T, Wareham, N J, Travis, R C, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Masala, G, Agnoli, C, Tumino, R, Mattiello, A, Peeters, P H, Weiderpass, E, Palmqvist, R, Ljuslinder, I, Gunter, M, Lu, Y, Cross, A J, Riboli, E, Vineis, P & Aleksandrova, K 2016, ' Cellular immune activity biomarker neopterin is associated hyperlipidemia : results from a large population-based study ', Immunity & ageing : I & A, vol. 13, no. 5, pp. 5 . https://doi.org/10.1186/s12979-016-0059-y
Immunity & ageing, 13: 5
Chuang, S C, Boeing, H, Vollset, S E, Midttun, O, Ueland, P M, Bueno-de-Mesquita, B, Lajous, M, Fagherazzi, G, Boutron-Ruault, M C, Kaaks, R, Kuehn, T, Pischon, T, Drogan, D, Tjonneland, A, Overvad, K, Quiros, J R, Agudo, A, Molina-Montes, E, Dorronsoro, M, Huerta, J M, Barricarte, A, Khaw, K T, Wareham, N J, Travis, R C, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Masala, G, Agnoli, C, Tumino, R, Mattiello, A, Peeters, P H, Weiderpass, E, Palmqvist, R, Ljuslinder, I, Gunter, M, Cross, A J, Riboli, E, Vineis, P & Aleksandrova, K 2016, ' Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study ', Immunity and Ageing . https://doi.org/10.1186/s12979-016-0059-y
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
ISSN: 1742-4933
Popis: BACKGROUND: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC).RESULTS: Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p CONCLUSIONS: These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS.
Databáze: OpenAIRE
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