Effects of omentectomy in addition to sleeve gastrectomy on the metabolic and inflammatory profiles of obese rats
| Autor: | Alfredo Maurício Batista de Paula, João Marcus Oliveira Andrade, Sérgio Henrique Sousa Santos, Thaísa Soares Crespo, André Luiz Sena Guimarães, Antonio Sergio Barcala Jorge |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Sleeve gastrectomy Intra-Abdominal Fat medicine.medical_treatment Bariatric Surgery Adipose tissue 030209 endocrinology & metabolism Diet High-Fat Random Allocation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Gastrectomy Weight loss Internal medicine Weight Loss medicine Animals Rats Wistar Emagrecimento Gastrectomia Cirurgia bariátrica business.industry Cholesterol Sham surgery Obesity Morbid Surgery Inflamação Omentectomy Endocrinology Obesidade chemistry Cytokines 030211 gastroenterology & hepatology medicine.symptom business Omentum Biomarkers |
| Zdroj: | Repositório Institucional da UFMG Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
| ISSN: | 1550-7289 |
| Popis: | Background: visceral obesity has been considered a risk factor for metabolic and cardiovascular complications. In an attempt to reduce the visceral adipose tissue, omentectomy has been proposed to be performed along with bariatric surgery. Objective: the goal of this study was to evaluate whether omentectomy associated with sleeve gastrectomy (SG) is beneficial to the inflammatory and metabolic profile of rats fed a standard diet (STD) or high-fat diet (HFD). Setting: University hospital, Brazil. Methods: for this experiment, male Wistar rats were randomly divided into 6 groups as follows: sham surgery (STD+L or HFD+L), SG alone (STD+SG or HFD+SG), or SG with omentectomy (STD+SGO or HFD+SGO). Anthropometric data and metabolic profiles were evaluated, and the tissue expression of inflammatory markers in the visceral adipose tissue was measured. Results: in rats with diet-induced obesity treated with SG with or without omentectomy, there was a reduction in weight (HFD+SG: P |
| Databáze: | OpenAIRE |
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