Gut Mucosal Proteins and Bacteriome Are Shaped by the Saturation Index of Dietary Lipids
| Autor: | Yee Kwan Chan, Sandeep K. Gill, Kirsty Brown, Deanna L. Gibson, Candice Quin, Nijiati Abulizi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Calorie gut microbiome Gut flora short-chain fatty acid metabolism Fats Mice RNA Ribosomal 16S Food science Intestinal Mucosa 16S rRNA gene amplicon sequencing 2. Zero hunger chemistry.chemical_classification Nutrition and Dietetics biology Fatty Acids monounsaturated fatty acids 3. Good health Milk Proteome Female lcsh:Nutrition. Foods and food supply Polyunsaturated fatty acid polyunsaturated fatty acids Colon proteome lcsh:TX341-641 Diet High-Fat Article dietary lipids 03 medical and health sciences medicine Animals saturated fatty acids Microbiome Olive Oil 030109 nutrition & dietetics Host-microbe interactions Bacteriome medicine.disease biology.organism_classification Dietary Fats Gastrointestinal Microbiome Mice Inbred C57BL 030104 developmental biology chemistry Corn Oil Dysbiosis Corn oil Food Science |
| Zdroj: | Nutrients Volume 11 Issue 2 Nutrients, Vol 11, Iss 2, p 418 (2019) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu11020418 |
| Popis: | The dynamics of the tripartite relationship between the host, gut bacteria and diet in the gut is relatively unknown. An imbalance between harmful and protective gut bacteria, termed dysbiosis, has been linked to many diseases and has most often been attributed to high-fat dietary intake. However, we recently clarified that the type of fat, not calories, were important in the development of murine colitis. To further understand the host-microbe dynamic in response to dietary lipids, we fed mice isocaloric high-fat diets containing either milk fat, corn oil or olive oil and performed 16S rRNA gene sequencing of the colon microbiome and mass spectrometry-based relative quantification of the colonic metaproteome. The corn oil diet, rich in omega-6 polyunsaturated fatty acids, increased the potential for pathobiont survival and invasion in an inflamed, oxidized and damaged gut while saturated fatty acids promoted compensatory inflammatory responses involved in tissue healing. We conclude that various lipids uniquely alter the host-microbe interaction in the gut. While high-fat consumption has a distinct impact on the gut microbiota, the type of fatty acids alters the relative microbial abundances and predicted functions. These results support that the type of fat are key to understanding the biological effects of high-fat diets on gut health. |
| Databáze: | OpenAIRE |
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