A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS
Autor: | Rex Kerr, Alex L. Kolodkin, Joseph C. Ayoob, Tomoko Ohyama, Benjamin J. Andreone, Liqun Luo, Lora B. Sweeney, Kayam Chak, Marta Zlatic, Zhuhao Wu |
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Rok vydání: | 2011 |
Předmět: |
Central Nervous System
animal structures Embryo Nonmammalian Body Patterning Neuroscience(all) Movement Central nervous system Green Fluorescent Proteins Sensory system Nerve Tissue Proteins Receptors Cell Surface Semaphorins Biology Vibration Animals Genetically Modified 03 medical and health sciences 0302 clinical medicine Semaphorin Physical Stimulation medicine Animals Drosophila Proteins Axon 030304 developmental biology Neurons 0303 health sciences Afferent Pathways Membrane Glycoproteins Behavior Animal General Neuroscience Plexin Gene Expression Regulation Developmental Alkaline Phosphatase Axons medicine.anatomical_structure Mutation biology.protein Drosophila Signal transduction Neuroscience 030217 neurology & neurosurgery Drosophila Protein Signal Transduction |
Zdroj: | Neuron. 70(2) |
ISSN: | 1097-4199 |
Popis: | SummaryLongitudinal axon fascicles within the Drosophila embryonic CNS provide connections between body segments and are required for coordinated neural signaling along the anterior-posterior axis. We show here that establishment of select CNS longitudinal tracts and formation of precise mechanosensory afferent innervation to the same CNS region are coordinately regulated by the secreted semaphorins Sema-2a and Sema-2b. Both Sema-2a and Sema-2b utilize the same neuronal receptor, plexin B (PlexB), but serve distinct guidance functions. Localized Sema-2b attraction promotes the initial assembly of a subset of CNS longitudinal projections and subsequent targeting of chordotonal sensory afferent axons to these same longitudinal connectives, whereas broader Sema-2a repulsion serves to prevent aberrant innervation. In the absence of Sema-2b or PlexB, chordotonal afferent connectivity within the CNS is severely disrupted, resulting in specific larval behavioral deficits. These results reveal that distinct semaphorin-mediated guidance functions converge at PlexB and are critical for functional neural circuit assembly. |
Databáze: | OpenAIRE |
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