Changes in distortion of two-tone cochlear microphonic and otoacoustic emission signals during an acute endolymphatic hydrops in the guinea pig
| Autor: | W. L. Valk, Hero P. Wit, F. W. J. Albers |
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| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Endocochlear potential Guinea Pigs Otoacoustic Emissions Spontaneous cochlear transducer Otoacoustic emission Cochlear duct acute endolymphatic hydrops Audiology PRESSURE operating point Medicine Animals Inner ear Endolymphatic Hydrops Endolymphatic hydrops Meniere Disease business.industry INNER-EAR ELECTROCOCHLEOGRAPHY General Medicine Meniere's disease Electrocochleography medicine.disease MENIERES-DISEASE Audiometry Evoked Response MODEL Disease Models Animal medicine.anatomical_structure Otorhinolaryngology Acute Disease Cochlear Microphonic Potentials distortion business Cochlear microphonic potential |
| Zdroj: | European Archives of Oto-Rhino-Laryngology, 263(5), 430-434. SPRINGER |
| ISSN: | 1434-4726 0937-4477 |
| Popis: | An acute endolymphatic hydrops was induced by the injection of 1.1 mu l of artificial endolymph into the scala media of guinea pig cochleas. This volume corresponds with an acute endolymphatic hydrops of 23%. During and after the injection, cochlear function was assessed by measuring the 2f(1)-f(2) and f(2)-f(1) distortion products in cochlear microphonics (CMDP) and the 2f(1)-f(2) distortion product otoacoustic emission (DPOAE). A reversible pressure increase of 23 Pa and a relatively stable endocochlear potential (EP) were accompanied by a mean decrease in 2f(1)-f(2) DPOAE of only 3.4 dB. Similarly, the 2f(1)-f(2) CMDP amplitude change was minimal during and after the injection. The only substantial change was measured in the f(2)-f(1) CMDP amplitude. The measured range of distortion amplitudes during an acute endolymphatic hydrops can be related to small changes in the cochlear transducer operating point. |
| Databáze: | OpenAIRE |
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