Mitochondrial HSP70 cognate-mediated differential expression of JNK1/2 in the pollution stressed grey mullets, Mugil cephalus
| Autor: | B. Vijaya Geetha, Ekambaram Padmini |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
MAPK/ERK pathway
Physiology Molecular Sequence Data Cellular homeostasis Aquatic Science Biology medicine.disease_cause Biochemistry Stress Physiological Transcription (biology) Botany medicine Animals Mitogen-Activated Protein Kinase 9 HSP70 Heat-Shock Proteins Mitogen-Activated Protein Kinase 8 RNA Messenger Sulfhydryl Compounds Gene Base Sequence Kinase General Medicine Glutathione Smegmamorpha Genes bcl-2 Mitochondria Hsp70 Cell biology Oxidative Stress Gene Expression Regulation Phosphorylation Estuaries Reactive Oxygen Species Oxidation-Reduction Water Pollutants Chemical Oxidative stress |
| Zdroj: | Fish Physiology and Biochemistry. 38:1257-1271 |
| ISSN: | 1573-5168 0920-1742 |
| Popis: | Cells have evolved different networks of cellular stress responses to adapt during environmental changes and survive combating wide variety of stress. Mitochondrial heat shock protein 70 (mtHSP70) are essential for maintaining cellular homeostasis. c-Jun-N terminal kinase (JNK), a subfamily of MAPK, plays a key role in the transmission of extracellular signal for survival and death. In the present investigation, the differential expression of phosphorylated JNK1/2 with corresponding increases in heat shock transcription factor-1 (HSF-1) under high levels of B-cell lymphoma 2 (Bcl-2), HSP70 transcripts (twofold) and mtHSP70 has been correlated with fish survival in polluted Ennore estuary. This study suggests that in Ennore sample, the amplification in HSP70 transcripts along with corresponding mtHSP70 overexpression might be due to activation of JNK1/2 and HSF-1. This would influence the expression of Bcl-2 protein involved in mitochondrial survival under pollution-stressed condition. |
| Databáze: | OpenAIRE |
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