Transient Increase of Interferon-Stimulated Genes and No Clinical Benefit by Chloroquine Treatment During Acute Simian Immunodeficiency Virus Infection of Macaques
| Autor: | Melvin N. Doster, Genoveffa Franchini, Zhong-Min Ma, Niklas Lindegardh, Monica Vaccari, Claudio Fenizia, Gene M. Shearer, Anna Hryniewicz, Joel Tarning, Christopher J. Miller, Adriano Boasso, Alan L. Landay |
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| Rok vydání: | 2014 |
| Předmět: |
Clinical Sciences
Immunology Simian Acquired Immunodeficiency Syndrome Biology medicine.disease_cause Asymptomatic Outcomes Research Virus Vaccine Related Acquired immunodeficiency syndrome (AIDS) Interferon Chloroquine Virology Genetics medicine Animals Immunologic Factors Gene Prevention Simian immunodeficiency virus Evaluation of treatments and therapeutic interventions medicine.disease Macaca mulatta Treatment Outcome Good Health and Well Being Infectious Diseases 6.1 Pharmaceuticals HIV/AIDS Simian Immunodeficiency Virus medicine.symptom Infection Malaria medicine.drug |
| Zdroj: | AIDS research and human retroviruses, vol 30, iss 4 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2013.0218 |
| Popis: | Simian immunodeficiency virus (SIV) infection leads to AIDS in experimentally infected Rhesus macaques similarly to HIV-infected humans. In contrast, SIV infection of natural hosts is characterized by a down-regulation of innate acute responses to the virus within a few weeks of infection and results in limited pathology. Chloroquine (CQ) has been used in the treatment or prevention of malaria and has recently been shown to cause a decrease of immune activation and CD4 cell loss in HIV-infected individuals treated with antiretroviral therapy. Here, we treated Rhesus macaques with CQ during the acute phase of SIVmac251 infection with the intent to decrease viral-induced immune activation and possibly limit disease progression. Contrary to what was expected, CQ treatment resulted in a temporary increased expression of interferon (IFN)-stimulating genes and it worsened the recovery of CD4(+) T cells in the blood. Our findings confirm recent results observed in asymptomatic HIV-infected patients and suggest that CQ does not provide an obvious benefit in the absence of antiretroviral therapy. |
| Databáze: | OpenAIRE |
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