Resistance Selection Studies Comparing the Activity of Razupenem (PTZ601) to Vancomycin and Linezolid against Eight Methicillin-Resistant and Two Methicillin-Susceptible Staphylococcus aureus Strains
| Autor: | Linda Beachel, Catherine Clark, Pamela McGhee, Peter C. Appelbaum, Bonifacio Dewasse, Klaudia Kosowska-Shick |
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| Rok vydání: | 2009 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus Meticillin Microbial Sensitivity Tests Biology medicine.disease_cause Microbiology Methicillin chemistry.chemical_compound Vancomycin Drug Resistance Multiple Bacterial Acetamides medicine Pharmacology (medical) Oxazolidinones Antibacterial agent Pharmacology Linezolid Methicillin-resistant Staphylococcus aureus Anti-Bacterial Agents Razupenem Infectious Diseases chemistry Susceptibility Methicillin Susceptible Staphylococcus Aureus medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 53:3118-3121 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Multistep and single-step resistance selection studies were performed with razupenem, linezolid, and vancomycin against 10 methicillin (meticillin)-resistant and -susceptible Staphylococcus aureus strains. After 20 daily subcultures, razupenem yielded only clones with MICs of >4 μg/ml in one strain (8 μg/ml) whose parent's MIC was already 4 μg/ml. After 18 to 49 passages in 6/10 strains, razupenem MICs rose from 0.016 to 2 μg/ml (parents) to 0.125 to 8 μg/ml (with clones stable after 10 drug-free subcultures). Single-step mutant selection frequencies were similarly low for razupenem and comparators. |
| Databáze: | OpenAIRE |
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